Formulation and evaluation of natural antioxidant cream comprising methanolic peel extract of Dimocarpus longan

Ravindran Muthukumarasamy, Alifah Ilyana, Nur ‘Afini Fithriyaani, Nur Ain Najihah, Nur Asyiqin, Mahendran Sekar

Research output: Contribution to journalArticleResearch

19 Citations (Scopus)

Abstract

Photo aging is a common problem that occurs in our community due to ongoing exposure to ultraviolet rays. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. Thus, the present study was to prepare and evaluate the antioxidant cream comprising the methanolic peel extracts of Dimocarpus longan for their radical scavenging activity. Antioxidant activity of peels and seeds methanolic extract (by continuous hot percolation-soxhletation) of D. longan was assessed by using stable 2,2 -Diphenyl-1-picryl hydrazyl (DPPH). The extract of the D. longan fruits contained three major polyphenolic compounds which are corilagin, gallic acid, and ellagic acid which are responsible for the antioxidant properties. Methanolic extracts of both peels and seeds of D. longan exhibited high radical scavenging properties, the IC50 result revealed that peels extract were having higher antioxidant properties with 23.5 µg/ml compared to the seeds 32.13 µg/ml. Based on the higher scavenging activity the peels was chosen to prepare as formulation. Thus, the cream was formulated with 2.5% of peels extract by fusion method with incorporation of two different emulsifying agents for two formulations (F1 & F2). The evaluation of the formulations was done on different parameters like pH, spreadability, rheological study, non-volatile matter at 105 °C, physical stability of cream and microbial limit test. Both the formulations (F1 & F2) were showed good pH, homogeneity, appearance, ease to remove, good consistency, spreadability and no microbial growth. However, after four weeks of storage formulation of F1 showed cracking and phase separation. The evaluation parameters of the formulated cream F2 showed good results and are safe to use for skin. The present results indicates that the D. longan fruit peel extract has a good potential for cosmetic product development.

Original languageEnglish
Pages (from-to)1305-1309
Number of pages5
JournalInternational Journal of Pharmaceutical and Clinical Research
Volume8
Issue number9
Publication statusPublished - Sept 2016
Externally publishedYes

Keywords

  • Antioxidant
  • Dimocarpus longan
  • DPPH
  • Evaluation
  • Photoaging

Cite this