Formulation and characterization of nanoliposomal 5-fluorouracil for cancer nanotherapy

Aliaa N ElMeshad, Seyyed M R Mortazavi, Mhd Reza Mozafari

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

A scalable and safe method was developed to prepare nanoliposome carriers for the entrapment and delivery of 5-fluorouracil (5-FU). The carrier systems were composed of endogenously occurring dipalmitoylphosphatidylcholine (DPPC), negatively charged dicetylphosphate (DCP), cholesterol (CHOL) and glycerol (3 , v/v). Nanoliposomes were prepared by the heating method in which no harmful chemical or procedure is involved. Results indicated fast and reproducible formation of non-toxic liposomes that possess high entrapment efficiency (up to 96.9 ) and vesicle size range of ca. 530-620 nm. Transmission electron and optical micrographs of the 5-FU liposomes revealed that they were spherical and some were multilayered. There was an increase in the release rate of 5-FU from the liposomes prepared with a high ratio of drug:lipid. The release data showed that the highest release rates were obtained for nanoliposomes containing 5-FU with the drug concentration of 500 mM and that it followed the diffusion model. Nanoliposome preparation method introduced here has the potential of large-scale manufacture of safe and efficient carriers of 5-FU.
Original languageEnglish
Pages (from-to)1 - 9
Number of pages9
JournalJournal of Liposome Research
Volume24
Issue number1
DOIs
Publication statusPublished - 2014

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