Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network

Patrick P L Tam, Nicolas Fossat, Emilie Wilkie, David A F Loebel, Chi Kin Ip, Mirana Ramialison

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start at gastrulation, are accompanied by the spatiotemporal activity of transcription factors and signaling pathways that drives lineage specification, germ layer formation, and cell/tissue movement. The morphogenesis, regionalization, and patterning of the brain and craniofacial structures rely on the function of LIM-domain, homeodomain, and basic helix-loop-helix transcription factors. These factors constitute the central nodes of a gene regulatory network (GRN) which encompasses and intersects with signaling pathways involved with head formation. It is predicted that the functional output of this head GRN impacts on cellular function and cell-cell interactions that are essential for lineage differentiation and tissue modeling, which are key processes underpinning the formation of the head.
Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
Subtitle of host publicationEssays on Developmental Biology, Part B
EditorsPaul M Wassarman
Place of PublicationCambridge MA USA
PublisherAcademia Press
Pages497-521
Number of pages25
Volume117
Edition1st
ISBN (Print)978-0-12-801382-3
DOIs
Publication statusPublished - 2016

Publication series

NameCurrent Topics in Developmental Biology
PublisherAcademic Press
Volume117
ISSN (Print)0070-2153

Cite this

Tam, P. P. L., Fossat, N., Wilkie, E., Loebel, D. A. F., Ip, C. K., & Ramialison, M. (2016). Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. In P. M. Wassarman (Ed.), Current Topics in Developmental Biology: Essays on Developmental Biology, Part B (1st ed., Vol. 117, pp. 497-521). (Current Topics in Developmental Biology; Vol. 117). Cambridge MA USA: Academia Press. https://doi.org/10.1016/bs.ctdb.2015.11.019
Tam, Patrick P L ; Fossat, Nicolas ; Wilkie, Emilie ; Loebel, David A F ; Ip, Chi Kin ; Ramialison, Mirana. / Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. Current Topics in Developmental Biology: Essays on Developmental Biology, Part B. editor / Paul M Wassarman. Vol. 117 1st. ed. Cambridge MA USA : Academia Press, 2016. pp. 497-521 (Current Topics in Developmental Biology).
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Tam, PPL, Fossat, N, Wilkie, E, Loebel, DAF, Ip, CK & Ramialison, M 2016, Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. in PM Wassarman (ed.), Current Topics in Developmental Biology: Essays on Developmental Biology, Part B. 1st edn, vol. 117, Current Topics in Developmental Biology, vol. 117, Academia Press, Cambridge MA USA, pp. 497-521. https://doi.org/10.1016/bs.ctdb.2015.11.019

Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. / Tam, Patrick P L; Fossat, Nicolas; Wilkie, Emilie; Loebel, David A F; Ip, Chi Kin; Ramialison, Mirana.

Current Topics in Developmental Biology: Essays on Developmental Biology, Part B. ed. / Paul M Wassarman. Vol. 117 1st. ed. Cambridge MA USA : Academia Press, 2016. p. 497-521 (Current Topics in Developmental Biology; Vol. 117).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AB - The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start at gastrulation, are accompanied by the spatiotemporal activity of transcription factors and signaling pathways that drives lineage specification, germ layer formation, and cell/tissue movement. The morphogenesis, regionalization, and patterning of the brain and craniofacial structures rely on the function of LIM-domain, homeodomain, and basic helix-loop-helix transcription factors. These factors constitute the central nodes of a gene regulatory network (GRN) which encompasses and intersects with signaling pathways involved with head formation. It is predicted that the functional output of this head GRN impacts on cellular function and cell-cell interactions that are essential for lineage differentiation and tissue modeling, which are key processes underpinning the formation of the head.

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Tam PPL, Fossat N, Wilkie E, Loebel DAF, Ip CK, Ramialison M. Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. In Wassarman PM, editor, Current Topics in Developmental Biology: Essays on Developmental Biology, Part B. 1st ed. Vol. 117. Cambridge MA USA: Academia Press. 2016. p. 497-521. (Current Topics in Developmental Biology). https://doi.org/10.1016/bs.ctdb.2015.11.019