The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start at gastrulation, are accompanied by the spatiotemporal activity of transcription factors and signaling pathways that drives lineage specification, germ layer formation, and cell/tissue movement. The morphogenesis, regionalization, and patterning of the brain and craniofacial structures rely on the function of LIM-domain, homeodomain, and basic helix-loop-helix transcription factors. These factors constitute the central nodes of a gene regulatory network (GRN) which encompasses and intersects with signaling pathways involved with head formation. It is predicted that the functional output of this head GRN impacts on cellular function and cell-cell interactions that are essential for lineage differentiation and tissue modeling, which are key processes underpinning the formation of the head.
|Title of host publication||Current Topics in Developmental Biology|
|Subtitle of host publication||Essays on Developmental Biology, Part B|
|Editors||Paul M Wassarman|
|Place of Publication||Cambridge MA USA|
|Number of pages||25|
|Publication status||Published - 2016|
|Name||Current Topics in Developmental Biology|