Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network

Patrick P L Tam, Nicolas Fossat, Emilie Wilkie, David A F Loebel, Chi Kin Ip, Mirana Ramialison

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

4 Citations (Scopus)


The embryonic head is the first major body part to be constructed during embryogenesis. The allocation and the assembly of the progenitor tissues, which start at gastrulation, are accompanied by the spatiotemporal activity of transcription factors and signaling pathways that drives lineage specification, germ layer formation, and cell/tissue movement. The morphogenesis, regionalization, and patterning of the brain and craniofacial structures rely on the function of LIM-domain, homeodomain, and basic helix-loop-helix transcription factors. These factors constitute the central nodes of a gene regulatory network (GRN) which encompasses and intersects with signaling pathways involved with head formation. It is predicted that the functional output of this head GRN impacts on cellular function and cell-cell interactions that are essential for lineage differentiation and tissue modeling, which are key processes underpinning the formation of the head.
Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
Subtitle of host publicationEssays on Developmental Biology, Part B
EditorsPaul M Wassarman
Place of PublicationCambridge MA USA
PublisherAcademia Press
Number of pages25
ISBN (Print)978-0-12-801382-3
Publication statusPublished - 2016

Publication series

NameCurrent Topics in Developmental Biology
PublisherAcademic Press
ISSN (Print)0070-2153

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