Forget about thrombosis: Platelets and Alzheimer's disease, yet another sticky situation

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Abstract

In this issue of Science Signaling, Donner et al. define a highly interesting role for platelets in mediating the pathogenesis of Alzheimer's disease via a mechanism linked to integrin aIIbb3 outside-in signaling and adenosine diphosphate release. These findings raise the intriguing prospect of harnessing antiplatelet drugs for disrupting the nexus between Ab-induced activated platelets and Ab fibril and aggregate formation.

Original languageEnglish
Article numberfs9
Number of pages3
JournalScience Signaling
Volume9
Issue number429
DOIs
Publication statusPublished - 24 May 2016

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