Forensic interrogation of diabetic endothelitis in cardiovascular diseases and clinical translation in heart failure

Merlin C. Thomas, Pupalan Iyngkaran

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Diabetic heart disease (DHD) can be classified as a primary consequence from several pathophysiological manifestation of diabetes mellitus (DM) on cardiac tissues or secondarily in extracardiac tissues and is encountered as either primary or secondary complications of DM. Endothelitis is inflammation of the vascular endothelium and is likely to be seen in the majority of patients who start to manifest an end organ complication of DM in this case DHD. Diabetes is a leading cause for many cardiovascular syndromes and diseases including congestive heart failure (CHF) however much remains unknown about the transition from diagnosed DM to clinical state and the contribution of the various mechanical and counterregulatory systems in the manifested complaint. Diastolic heart failure or heart failure with preserved ejection fraction (DHF/HFpEF), accounts for half of all CHF presentations, has DM as a major contributor, however, there remain large gaps in clinical and pathophysiological understanding. This review aims to explore the microscopic aspects in diabetic endothelitis and provide a clinical link to with context to HFpEF.

Original languageEnglish
Pages (from-to)409-418
Number of pages10
JournalWorld Journal of Cardiology
Volume12
Issue number8
DOIs
Publication statusPublished - 26 Aug 2020

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Diabetic heart disease
  • Diastolic heart failure
  • Endothelitis
  • Heart failure with preserved ejection fraction
  • Inflammation

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