TY - JOUR
T1 - For Whom the Bell Tolls
T2 - The Structure of the Dead Kinase, IRAK3
AU - Horne, Christopher R.
AU - Murphy, James M.
N1 - Funding Information:
J.M.M. thanks the National Health and Medical Research Council of Australia ( NHMRC ) for fellowship support ( 1172929 ). The authors gratefully acknowledge infrastructure support from NHMRC IRIISS ( 9000653 ) and the Victorian State Government Operational Infrastructure Support Scheme .
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/3/4
Y1 - 2021/3/4
N2 - In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.
AB - In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.
UR - https://www.scopus.com/pages/publications/85101646511
U2 - 10.1016/j.str.2021.01.011
DO - 10.1016/j.str.2021.01.011
M3 - Editorial
C2 - 33667374
AN - SCOPUS:85101646511
SN - 0969-2126
VL - 29
SP - 197
EP - 199
JO - Structure
JF - Structure
IS - 3
ER -