Follicular B helper T cells in antibody responses and autoimmunity

Carola G. Vinuesa, Stuart G. Tangye, Bernhard Moser, Charles R. Mackay

Research output: Contribution to journalReview ArticleResearchpeer-review

466 Citations (Scopus)

Abstract

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4+ T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.

Original languageEnglish
Pages (from-to)853-865
Number of pages13
JournalNature Reviews Immunology
Volume5
Issue number11
DOIs
Publication statusPublished - 1 Nov 2005
Externally publishedYes

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