Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

Li Yan; Wei Chen; Xiaoyue Zhu; Longbiao Huang; Zhigang Wang; Guangyu Zhu; V. A.L. Roy; K. N. Yu; Xianfeng Chen

doi:10.1039/c3cc45714a

Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

Li Yan, Wei Chen, Xiaoyue Zhu, Longbiao Huang, Zhigang Wang, Guangyu Zhu, V. A.L. Roy, K. N. Yu, Xianfeng Chen

Research output: Contribution to journal › Article › Research › peer-review

63 Citations (Scopus)

Abstract

Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

Original language	English
Pages (from-to)	10938-10940
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	93
DOIs	https://doi.org/10.1039/c3cc45714a
Publication status	Published - 4 Dec 2013
Externally published	Yes

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title = "Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery",

abstract = "Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt\% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.",

author = "Li Yan and Wei Chen and Xiaoyue Zhu and Longbiao Huang and Zhigang Wang and Guangyu Zhu and Roy, \{V. A.L.\} and Yu, \{K. N.\} and Xianfeng Chen",

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T1 - Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

AU - Yan, Li

AU - Chen, Wei

AU - Zhu, Xiaoyue

AU - Huang, Longbiao

AU - Wang, Zhigang

AU - Zhu, Guangyu

AU - Roy, V. A.L.

AU - Yu, K. N.

AU - Chen, Xianfeng

PY - 2013/12/4

Y1 - 2013/12/4

N2 - Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

AB - Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

UR - https://www.scopus.com/pages/publications/84886839424

U2 - 10.1039/c3cc45714a

DO - 10.1039/c3cc45714a

M3 - Article

C2 - 24129414

AN - SCOPUS:84886839424

SN - 1359-7345

VL - 49

SP - 10938

EP - 10940

JO - Chemical Communications

JF - Chemical Communications

IS - 93

ER -

Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

Abstract

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