Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

Li Yan, Wei Chen, Xiaoyue Zhu, Longbiao Huang, Zhigang Wang, Guangyu Zhu, V. A.L. Roy, K. N. Yu, Xianfeng Chen

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52 Citations (Scopus)

Abstract

Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.

Original languageEnglish
Pages (from-to)10938-10940
Number of pages3
JournalChemical Communications
Volume49
Issue number93
DOIs
Publication statusPublished - 4 Dec 2013
Externally publishedYes

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