Folate binding protein - Outlook for drug delivery applications

Rachel L. Merzel, Jun-Jie Chen, E. Neil G. Marsh, Mark M. Banaszak Holl

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini-review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight-binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalChinese Chemical Letters
Volume26
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015
Externally publishedYes

Keywords

  • Drug delivery
  • Folate binding protein
  • Folate conjugate
  • Folic acid
  • Serum protein

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