Abstract
Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini-review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight-binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.
| Original language | English |
|---|---|
| Pages (from-to) | 426-430 |
| Number of pages | 5 |
| Journal | Chinese Chemical Letters |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2015 |
| Externally published | Yes |
Keywords
- Drug delivery
- Folate binding protein
- Folate conjugate
- Folic acid
- Serum protein
Cite this
}
Folate binding protein - Outlook for drug delivery applications. / Merzel, Rachel L.; Chen, Jun-Jie; Marsh, E. Neil G.; Holl, Mark M. Banaszak.
In: Chinese Chemical Letters, Vol. 26, No. 4, 01.04.2015, p. 426-430.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Folate binding protein - Outlook for drug delivery applications
AU - Merzel, Rachel L.
AU - Chen, Jun-Jie
AU - Marsh, E. Neil G.
AU - Holl, Mark M. Banaszak
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini-review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight-binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.
AB - Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini-review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight-binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.
KW - Drug delivery
KW - Folate binding protein
KW - Folate conjugate
KW - Folic acid
KW - Serum protein
UR - http://www.scopus.com/inward/record.url?scp=84939972993&partnerID=8YFLogxK
U2 - 10.1016/j.cclet.2014.12.015
DO - 10.1016/j.cclet.2014.12.015
M3 - Review Article
VL - 26
SP - 426
EP - 430
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
SN - 1001-8417
IS - 4
ER -