Focused review: Cytotoxic and antioxidant potentials of mangrove-derived streptomyces

Hooi Leng Ser, Loh Teng Hern Tan, Jodi Woan Fei Law, Kok Gan Chan, Acharaporn Duangjai, Surasak Saokaew, Priyia Pusparajah, Nurul Syakima Ab Mutalib, Tahir Mehmood Khan, Bey Hing Goh, Learn Han Lee

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Human life expectancy is rapidly increasing with an associated increasing burden of chronic diseases, such as neurodegenerative diseases and cancer. However, there is limited progress in finding effective treatment for these conditions. For this reason, members of the genus Streptomyces have been explored extensively over the past decades as these filamentous bacteria are highly efficient in producing bioactive compounds with human health benefits. Being ubiquitous in nature, streptomycetes can be found in both terrestrial and marine environments. Previously, two Streptomyces strains (MUSC 137T and MUM 256) isolated from mangrove sediments in Peninsular Malaysia demonstrated potent antioxidant and cytotoxic activities against several human cancer cell lines on bioactivity screening. These results illustrate the importance of streptomycetes from underexplored regions aside from the terrestrial ecosystem. Here we provide the insights and significance of Streptomyces species in the search of anticancer and/or chemopreventive agents and highlight the impact of next generation sequencing on drug discovery from the Streptomyces arsenal.

Original languageEnglish
Article number2065
Number of pages11
JournalFrontiers in Microbiology
Volume8
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Antioxidant
  • Bioactive
  • Cytotoxic
  • Mangrove
  • Streptomyces

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