Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

Nicholas L. Opie, Sam E. John, Gil S. Rind, Stephen M. Ronayne, Yan T. Wong, Giulia Gerboni, Peter E. Yoo, Timothy John Haynes Lovell, Theodore C. Scordas, Stefan L. Wilson, Anthony Dornom, Thomas Vale, Terence John O'Brien, David B Grayden, Clive Newton May, Thomas J Oxley

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson’s disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Here, we report the development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel. Following percutaneous angiographic implantation of the device in sheep, we observed stimulation-induced responses of the facial muscles and limbs of the animals, similar to those evoked by electrodes implanted via invasive surgery. Proximity of the electrode to the motor cortex, yet not its orientation, was integral to achieving reliable responses from discrete neuronal populations. The minimally invasive endovascular surgical approach offered by the stent-mounted electrode array might enable safe and efficacious stimulation of focal regions in the brain.

Original languageEnglish
Pages (from-to)907-914
Number of pages15
JournalNature Biomedical Engineering
Volume2
DOIs
Publication statusPublished - 1 Dec 2018

Cite this

Opie, Nicholas L. ; John, Sam E. ; Rind, Gil S. ; Ronayne, Stephen M. ; Wong, Yan T. ; Gerboni, Giulia ; Yoo, Peter E. ; Lovell, Timothy John Haynes ; Scordas, Theodore C. ; Wilson, Stefan L. ; Dornom, Anthony ; Vale, Thomas ; O'Brien, Terence John ; Grayden, David B ; May, Clive Newton ; Oxley, Thomas J. / Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent. In: Nature Biomedical Engineering. 2018 ; Vol. 2. pp. 907-914.
@article{d652e88edf0b49bdb2ff6a8044db7562,
title = "Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent",
abstract = "Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson’s disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Here, we report the development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel. Following percutaneous angiographic implantation of the device in sheep, we observed stimulation-induced responses of the facial muscles and limbs of the animals, similar to those evoked by electrodes implanted via invasive surgery. Proximity of the electrode to the motor cortex, yet not its orientation, was integral to achieving reliable responses from discrete neuronal populations. The minimally invasive endovascular surgical approach offered by the stent-mounted electrode array might enable safe and efficacious stimulation of focal regions in the brain.",
author = "Opie, {Nicholas L.} and John, {Sam E.} and Rind, {Gil S.} and Ronayne, {Stephen M.} and Wong, {Yan T.} and Giulia Gerboni and Yoo, {Peter E.} and Lovell, {Timothy John Haynes} and Scordas, {Theodore C.} and Wilson, {Stefan L.} and Anthony Dornom and Thomas Vale and O'Brien, {Terence John} and Grayden, {David B} and May, {Clive Newton} and Oxley, {Thomas J}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41551-018-0321-z",
language = "English",
volume = "2",
pages = "907--914",
journal = "Nature Biomedical Engineering",
issn = "2157-846X",
publisher = "Nature Publishing Group",

}

Opie, NL, John, SE, Rind, GS, Ronayne, SM, Wong, YT, Gerboni, G, Yoo, PE, Lovell, TJH, Scordas, TC, Wilson, SL, Dornom, A, Vale, T, O'Brien, TJ, Grayden, DB, May, CN & Oxley, TJ 2018, 'Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent' Nature Biomedical Engineering, vol. 2, pp. 907-914. https://doi.org/10.1038/s41551-018-0321-z

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent. / Opie, Nicholas L.; John, Sam E.; Rind, Gil S.; Ronayne, Stephen M.; Wong, Yan T.; Gerboni, Giulia; Yoo, Peter E.; Lovell, Timothy John Haynes; Scordas, Theodore C.; Wilson, Stefan L.; Dornom, Anthony; Vale, Thomas; O'Brien, Terence John; Grayden, David B; May, Clive Newton; Oxley, Thomas J.

In: Nature Biomedical Engineering, Vol. 2, 01.12.2018, p. 907-914.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent

AU - Opie, Nicholas L.

AU - John, Sam E.

AU - Rind, Gil S.

AU - Ronayne, Stephen M.

AU - Wong, Yan T.

AU - Gerboni, Giulia

AU - Yoo, Peter E.

AU - Lovell, Timothy John Haynes

AU - Scordas, Theodore C.

AU - Wilson, Stefan L.

AU - Dornom, Anthony

AU - Vale, Thomas

AU - O'Brien, Terence John

AU - Grayden, David B

AU - May, Clive Newton

AU - Oxley, Thomas J

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson’s disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Here, we report the development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel. Following percutaneous angiographic implantation of the device in sheep, we observed stimulation-induced responses of the facial muscles and limbs of the animals, similar to those evoked by electrodes implanted via invasive surgery. Proximity of the electrode to the motor cortex, yet not its orientation, was integral to achieving reliable responses from discrete neuronal populations. The minimally invasive endovascular surgical approach offered by the stent-mounted electrode array might enable safe and efficacious stimulation of focal regions in the brain.

AB - Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson’s disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Here, we report the development and application of a chronically implanted platinum electrode array mounted on a nitinol endovascular stent for the localized stimulation of cortical tissue from within a blood vessel. Following percutaneous angiographic implantation of the device in sheep, we observed stimulation-induced responses of the facial muscles and limbs of the animals, similar to those evoked by electrodes implanted via invasive surgery. Proximity of the electrode to the motor cortex, yet not its orientation, was integral to achieving reliable responses from discrete neuronal populations. The minimally invasive endovascular surgical approach offered by the stent-mounted electrode array might enable safe and efficacious stimulation of focal regions in the brain.

UR - http://www.scopus.com/inward/record.url?scp=85058037866&partnerID=8YFLogxK

U2 - 10.1038/s41551-018-0321-z

DO - 10.1038/s41551-018-0321-z

M3 - Article

VL - 2

SP - 907

EP - 914

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

SN - 2157-846X

ER -