Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis

Shaun L. Cloherty; Markus A. Hietanen; Gregg J. Suaning; Michael R. Ibbotson

doi:10.1109/IEMBS.2010.5625999

Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis

Shaun L. Cloherty, Markus A. Hietanen, Gregg J. Suaning, Michael R. Ibbotson

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

2 Citations (Scopus)

Abstract

We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.

Original language	English
Title of host publication	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc)
Pages	6765-6768
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2010.5625999
Publication status	Published - 2010
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2010 - Sheraton Buenos Aires Hotel, Buenos Aires, Argentina Duration: 31 Aug 2010 → 4 Sept 2010 Conference number: 32nd https://ieeexplore.ieee.org/xpl/conhome/5608545/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2010
Abbreviated title	EMBC 2010
Country/Territory	Argentina
City	Buenos Aires
Period	31/08/10 → 4/09/10
Internet address	https://ieeexplore.ieee.org/xpl/conhome/5608545/proceeding (Proceedings)

Access to Document

10.1109/IEMBS.2010.5625999

Cite this

Cloherty, S. L., Hietanen, M. A., Suaning, G. J., & Ibbotson, M. R. (2010). Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc) (pp. 6765-6768) https://doi.org/10.1109/IEMBS.2010.5625999

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title = "Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis",

abstract = "We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.",

author = "Cloherty, \{Shaun L.\} and Hietanen, \{Markus A.\} and Suaning, \{Gregg J.\} and Ibbotson, \{Michael R.\}",

note = "32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10), Buenos Aires, ARGENTINA, AUG 30-SEP 04, 2010; International Conference of the IEEE Engineering in Medicine and Biology Society 2010, EMBC 2010 ; Conference date: 31-08-2010 Through 04-09-2010",

year = "2010",

doi = "10.1109/IEMBS.2010.5625999",

language = "English",

isbn = "9781424441242",

pages = "6765--6768",

booktitle = "2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc)",

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Cloherty, SL, Hietanen, MA, Suaning, GJ & Ibbotson, MR 2010, Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc). pp. 6765-6768, International Conference of the IEEE Engineering in Medicine and Biology Society 2010, Buenos Aires, Argentina, 31/08/10. https://doi.org/10.1109/IEMBS.2010.5625999

Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis. / Cloherty, Shaun L.; Hietanen, Markus A.; Suaning, Gregg J. et al.
2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc). 2010. p. 6765-6768.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AU - Ibbotson, Michael R.

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