Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis

Shaun L. Cloherty, Markus A. Hietanen, Gregg J. Suaning, Michael R. Ibbotson

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

2 Citations (Scopus)

Abstract

We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a suprachoroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus. Our results: (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that suprachoroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.
Original languageEnglish
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (embc)
Pages6765-6768
Number of pages4
DOIs
Publication statusPublished - 2010
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2010 - Sheraton Buenos Aires Hotel, Buenos Aires, Argentina
Duration: 31 Aug 20104 Sep 2010
Conference number: 32nd
https://ieeexplore.ieee.org/xpl/conhome/5608545/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2010
Abbreviated titleEMBC 2010
CountryArgentina
CityBuenos Aires
Period31/08/104/09/10
Internet address

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