(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis

Michelle Ang Camerino, David Kenneth Chalmers, Philip Thompson

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An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown.
Original languageEnglish
Pages (from-to)2571 - 2573
Number of pages3
JournalOrganic and Biomolecular Chemistry
Issue number16
Publication statusPublished - 2013

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