TY - JOUR
T1 - Flt3 ligand-treated neonatal mice have increased innate immunity against intracellular pathogens and efficiently control virus infections
AU - Vollstedt, Sabine
AU - Franchini, Marco
AU - Hefti, Hans P.
AU - Odermatt, Bernhard
AU - O'Keeffe, Meredith
AU - Alber, Gottfried
AU - Glanzmann, Bettina
AU - Riesen, Matthias
AU - Ackermann, Mathias
AU - Suter, Mark
PY - 2003/3/3
Y1 - 2003/3/3
N2 - Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendritic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL treatment of newborn mice induced a >100-fold increase in the innate resistance against infection with herpes simplex virus type 1 and Listeria monocytogenes. This resistance required interferon (IFN)-α/β for viral and interleukin (IL)-12 for bacterial infections. Long-term survival after viral but not bacterial infection was increased ∼100-fold by FL treatment. After treatment, CD11c+/major histocompatibility complex type II+ and CD11c+/B220+ DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin. DC induction was independent of IFNs, IL-2, -4, -7, -9, -15, and mature T and B cells. The data suggest that FL increases the number of DCs in neonates and possibly in other immune-compromised individuals, which in turn improves IFN-α/β- and IL-12-associated immune responses.
AB - Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendritic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL treatment of newborn mice induced a >100-fold increase in the innate resistance against infection with herpes simplex virus type 1 and Listeria monocytogenes. This resistance required interferon (IFN)-α/β for viral and interleukin (IL)-12 for bacterial infections. Long-term survival after viral but not bacterial infection was increased ∼100-fold by FL treatment. After treatment, CD11c+/major histocompatibility complex type II+ and CD11c+/B220+ DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin. DC induction was independent of IFNs, IL-2, -4, -7, -9, -15, and mature T and B cells. The data suggest that FL increases the number of DCs in neonates and possibly in other immune-compromised individuals, which in turn improves IFN-α/β- and IL-12-associated immune responses.
KW - Bacteria
KW - DC
KW - IL
KW - Neonatal immune response
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=0037416137&partnerID=8YFLogxK
U2 - 10.1084/jem.20021900
DO - 10.1084/jem.20021900
M3 - Article
C2 - 12615899
AN - SCOPUS:0037416137
SN - 0022-1007
VL - 197
SP - 575
EP - 584
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -