Flow-rate-insensitive deterministic particle sorting using a combination of travelling and standing surface acoustic waves

Jia Wei Ng, David J. Collins, Citsabehsan Devendran, Ye Ai, Adrian Neild

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Manipulation of cells by acoustic forces in a continuous flow offers a means to sort on the basis of physical properties in a contactless, label-free and biocompatible manner. Many acoustic sorting systems rely on either standing waves or travelling waves alone and require specific exposure times to the acoustic field, fine-tuned by manipulating the bulk flow rate. In this work, we demonstrate a flow-rate-insensitive device for continuous particle sorting by employing a pressure field that utilises both travelling and standing acoustic wave components, whose non-uniform spatial distribution arises from the attenuation of a leaky surface acoustic wave. We show that in parts of the pressure field in which the travelling wave component dominates, particles migrate across multiple wavelengths. In doing so, they drift into areas of standing wave dominance, whereby particles are confined within their respective nodal positions. It is demonstrated that this final confinement location is dependent on the particle size and independent of the force field exposure time and thus the flow rate, permitting the continuous separation of 5.1-, 6.1- and 7.0-µm particles. Omitting the need to precisely control the bulk flow rate potentially enables sorting in systems in which flow is not driven by external pumps.

Original languageEnglish
Article number151
Number of pages12
JournalMicrofluidics and Nanofluidics
Volume20
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Acoustic radiation force
  • Acoustofluidics
  • Lab on a chip
  • Microfluidics
  • Particle sorting
  • Standing wave
  • Surface acoustic wave (SAW)
  • Travelling waves

Cite this

@article{b9ef10d6e5be4bc4987bbba5c97898b9,
title = "Flow-rate-insensitive deterministic particle sorting using a combination of travelling and standing surface acoustic waves",
abstract = "Manipulation of cells by acoustic forces in a continuous flow offers a means to sort on the basis of physical properties in a contactless, label-free and biocompatible manner. Many acoustic sorting systems rely on either standing waves or travelling waves alone and require specific exposure times to the acoustic field, fine-tuned by manipulating the bulk flow rate. In this work, we demonstrate a flow-rate-insensitive device for continuous particle sorting by employing a pressure field that utilises both travelling and standing acoustic wave components, whose non-uniform spatial distribution arises from the attenuation of a leaky surface acoustic wave. We show that in parts of the pressure field in which the travelling wave component dominates, particles migrate across multiple wavelengths. In doing so, they drift into areas of standing wave dominance, whereby particles are confined within their respective nodal positions. It is demonstrated that this final confinement location is dependent on the particle size and independent of the force field exposure time and thus the flow rate, permitting the continuous separation of 5.1-, 6.1- and 7.0-µm particles. Omitting the need to precisely control the bulk flow rate potentially enables sorting in systems in which flow is not driven by external pumps.",
keywords = "Acoustic radiation force, Acoustofluidics, Lab on a chip, Microfluidics, Particle sorting, Standing wave, Surface acoustic wave (SAW), Travelling waves",
author = "Ng, {Jia Wei} and Collins, {David J.} and Citsabehsan Devendran and Ye Ai and Adrian Neild",
year = "2016",
month = "11",
day = "1",
doi = "10.1007/s10404-016-1814-2",
language = "English",
volume = "20",
journal = "Microfluidics and Nanofluidics",
issn = "1613-4982",
publisher = "Springer-Verlag London Ltd.",
number = "11",

}

Flow-rate-insensitive deterministic particle sorting using a combination of travelling and standing surface acoustic waves. / Ng, Jia Wei; Collins, David J.; Devendran, Citsabehsan; Ai, Ye; Neild, Adrian.

In: Microfluidics and Nanofluidics, Vol. 20, No. 11, 151, 01.11.2016.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Flow-rate-insensitive deterministic particle sorting using a combination of travelling and standing surface acoustic waves

AU - Ng, Jia Wei

AU - Collins, David J.

AU - Devendran, Citsabehsan

AU - Ai, Ye

AU - Neild, Adrian

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Manipulation of cells by acoustic forces in a continuous flow offers a means to sort on the basis of physical properties in a contactless, label-free and biocompatible manner. Many acoustic sorting systems rely on either standing waves or travelling waves alone and require specific exposure times to the acoustic field, fine-tuned by manipulating the bulk flow rate. In this work, we demonstrate a flow-rate-insensitive device for continuous particle sorting by employing a pressure field that utilises both travelling and standing acoustic wave components, whose non-uniform spatial distribution arises from the attenuation of a leaky surface acoustic wave. We show that in parts of the pressure field in which the travelling wave component dominates, particles migrate across multiple wavelengths. In doing so, they drift into areas of standing wave dominance, whereby particles are confined within their respective nodal positions. It is demonstrated that this final confinement location is dependent on the particle size and independent of the force field exposure time and thus the flow rate, permitting the continuous separation of 5.1-, 6.1- and 7.0-µm particles. Omitting the need to precisely control the bulk flow rate potentially enables sorting in systems in which flow is not driven by external pumps.

AB - Manipulation of cells by acoustic forces in a continuous flow offers a means to sort on the basis of physical properties in a contactless, label-free and biocompatible manner. Many acoustic sorting systems rely on either standing waves or travelling waves alone and require specific exposure times to the acoustic field, fine-tuned by manipulating the bulk flow rate. In this work, we demonstrate a flow-rate-insensitive device for continuous particle sorting by employing a pressure field that utilises both travelling and standing acoustic wave components, whose non-uniform spatial distribution arises from the attenuation of a leaky surface acoustic wave. We show that in parts of the pressure field in which the travelling wave component dominates, particles migrate across multiple wavelengths. In doing so, they drift into areas of standing wave dominance, whereby particles are confined within their respective nodal positions. It is demonstrated that this final confinement location is dependent on the particle size and independent of the force field exposure time and thus the flow rate, permitting the continuous separation of 5.1-, 6.1- and 7.0-µm particles. Omitting the need to precisely control the bulk flow rate potentially enables sorting in systems in which flow is not driven by external pumps.

KW - Acoustic radiation force

KW - Acoustofluidics

KW - Lab on a chip

KW - Microfluidics

KW - Particle sorting

KW - Standing wave

KW - Surface acoustic wave (SAW)

KW - Travelling waves

UR - http://www.scopus.com/inward/record.url?scp=84992345157&partnerID=8YFLogxK

U2 - 10.1007/s10404-016-1814-2

DO - 10.1007/s10404-016-1814-2

M3 - Article

VL - 20

JO - Microfluidics and Nanofluidics

JF - Microfluidics and Nanofluidics

SN - 1613-4982

IS - 11

M1 - 151

ER -