Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Endometrial cancer is the most common invasive gynecological malignancy. Flotillin-1 is an integral membrane protein and estrogen responsive gene. Flotillin-1 expression and localization in human endometrial cancers grades 1-3 was investigated using real-time RT-PCR and immunohistochemistry. Flotillin-1 mRNA levels were unchanged in endometrial cancer versus benign endometrium. Flotillin-1 protein was significantly reduced in the epithelial compartment with increasing tumor grade, although levels increased in the tumor stroma across grades. We have identified a novel factor in human endometrial cancer and observed a shift in epithelial to stromal localization with increasing tumor grade in women.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalCancer Investigation
Volume34
Issue number1
DOIs
Publication statusPublished - 2 Jan 2016

Keywords

  • Endometrioid
  • Gynecological cancer
  • Lipid raft

Cite this

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title = "Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade",
abstract = "Endometrial cancer is the most common invasive gynecological malignancy. Flotillin-1 is an integral membrane protein and estrogen responsive gene. Flotillin-1 expression and localization in human endometrial cancers grades 1-3 was investigated using real-time RT-PCR and immunohistochemistry. Flotillin-1 mRNA levels were unchanged in endometrial cancer versus benign endometrium. Flotillin-1 protein was significantly reduced in the epithelial compartment with increasing tumor grade, although levels increased in the tumor stroma across grades. We have identified a novel factor in human endometrial cancer and observed a shift in epithelial to stromal localization with increasing tumor grade in women.",
keywords = "Endometrioid, Gynecological cancer, Lipid raft",
author = "Winship, {Amy Louise} and Kate Rainczuk and Evdokia Dimitriadis",
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doi = "10.3109/07357907.2015.1084313",
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Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade. / Winship, Amy Louise; Rainczuk, Kate; Dimitriadis, Evdokia.

In: Cancer Investigation, Vol. 34, No. 1, 02.01.2016, p. 26-31.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Rainczuk, Kate

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KW - Endometrioid

KW - Gynecological cancer

KW - Lipid raft

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