Flicking the molecular switch underlying MLKL-mediated necroptosis

Joanne M. Hildebrand, Isabelle S. Lucet, James M. Murphy

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4 Citations (Scopus)


The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.

Original languageEnglish
Article numbere985550
Number of pages3
JournalMolecular and Cellular Oncology
Issue number3
Publication statusPublished - 2015
Externally publishedYes

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