Flexible neural recording electrodes based on reduced graphene oxide interfaces

Miheng Dong; Patcharin Chen; Kun Zhou; Jason B. Marroquin; Minsu Liu; Sebastian Thomas; Harold A. Coleman; Dan Li; James B. Fallon; Mainak Majumder; Helena C. Parkington; John S. Forsythe

doi:10.1016/j.cej.2023.147067

Flexible neural recording electrodes based on reduced graphene oxide interfaces

Miheng Dong, Patcharin Chen, Kun Zhou, Jason B. Marroquin, Minsu Liu, Sebastian Thomas, Harold A. Coleman, Dan Li, James B. Fallon, Mainak Majumder, Helena C. Parkington, John S. Forsythe

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Conventional recording neural electrodes are made of stiff materials such as metal or silicon which triggers unwanted inflammation and does not provide intimate contact with brain tissue. Flexible neural electrodes have therefore been increasingly investigated to address these issues. In this study, we introduce reduced graphene oxide (rGO) recording electrodes in the format of 3-dimensional flexible membranes (rGO-3D) and 2-dimensional thin films (rGO-2D) for long-term and acute recordings, respectively. The rGO electrodes supported the functional development of cultured primary neurons and displayed good recording capabilities similar to conventional glass pipette and Pt ball electrodes in ex vivo and acute in vivo experiments. In vivo biocompatibility studies demonstrated the migration of neural processes onto the rGO-2D surface and within the rGO-3D electrodes, with the latter forming an intimate interpenetrating network. This study not only generates new knowledge to balance conductivity and porosity of rGO coatings but also provides in-depth evaluation of the physical and biological properties of such interfaces.

Original language	English
Article number	147067
Number of pages	12
Journal	Chemical Engineering Journal
Volume	478
DOIs	https://doi.org/10.1016/j.cej.2023.147067
Publication status	Published - 15 Dec 2023

Keywords

Flexible neural electrodes
Neural electrodes
Recording neural electrodes
Reduced graphene oxide

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10.1016/j.cej.2023.147067

Cite this

@article{ae0ee802ced249e6abd9868843af2035,

title = "Flexible neural recording electrodes based on reduced graphene oxide interfaces",

abstract = "Conventional recording neural electrodes are made of stiff materials such as metal or silicon which triggers unwanted inflammation and does not provide intimate contact with brain tissue. Flexible neural electrodes have therefore been increasingly investigated to address these issues. In this study, we introduce reduced graphene oxide (rGO) recording electrodes in the format of 3-dimensional flexible membranes (rGO-3D) and 2-dimensional thin films (rGO-2D) for long-term and acute recordings, respectively. The rGO electrodes supported the functional development of cultured primary neurons and displayed good recording capabilities similar to conventional glass pipette and Pt ball electrodes in ex vivo and acute in vivo experiments. In vivo biocompatibility studies demonstrated the migration of neural processes onto the rGO-2D surface and within the rGO-3D electrodes, with the latter forming an intimate interpenetrating network. This study not only generates new knowledge to balance conductivity and porosity of rGO coatings but also provides in-depth evaluation of the physical and biological properties of such interfaces.",

keywords = "Flexible neural electrodes, Neural electrodes, Recording neural electrodes, Reduced graphene oxide",

author = "Miheng Dong and Patcharin Chen and Kun Zhou and Marroquin, {Jason B.} and Minsu Liu and Sebastian Thomas and Coleman, {Harold A.} and Dan Li and Fallon, {James B.} and Mainak Majumder and Parkington, {Helena C.} and Forsythe, {John S.}",

note = "Funding Information: This research was supported the Australian Research Council Discovery Project (DP140100803) and the National Health and Medical Research Council (APP1122055) of the Australian Government. Funding Information: F. 4a was prepared using web interface provided by Figdraw. Authorized exported image ID: SSOIP455ce. The authors acknowledge the use of facilities and assistance of staff at the Monash X-ray Platform. The authors also acknowledge the use of instruments at the Monash Centre for Electron Microscopy, a Node of Microscopy Australia. Mainak Majumder acknowledges partial support for this work by the ARC Research Hub for Advanced Manufacturing with Two-Dimensional Materials (IH210100025). Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = dec,

day = "15",

doi = "10.1016/j.cej.2023.147067",

language = "English",

volume = "478",

journal = "Chemical Engineering Journal",

issn = "1385-8947",

publisher = "Elsevier",

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T1 - Flexible neural recording electrodes based on reduced graphene oxide interfaces

AU - Dong, Miheng

AU - Chen, Patcharin

AU - Zhou, Kun

AU - Marroquin, Jason B.

AU - Liu, Minsu

AU - Thomas, Sebastian

AU - Coleman, Harold A.

AU - Li, Dan

AU - Fallon, James B.

AU - Majumder, Mainak

AU - Parkington, Helena C.

AU - Forsythe, John S.

N1 - Funding Information: This research was supported the Australian Research Council Discovery Project (DP140100803) and the National Health and Medical Research Council (APP1122055) of the Australian Government. Funding Information: F. 4a was prepared using web interface provided by Figdraw. Authorized exported image ID: SSOIP455ce. The authors acknowledge the use of facilities and assistance of staff at the Monash X-ray Platform. The authors also acknowledge the use of instruments at the Monash Centre for Electron Microscopy, a Node of Microscopy Australia. Mainak Majumder acknowledges partial support for this work by the ARC Research Hub for Advanced Manufacturing with Two-Dimensional Materials (IH210100025). Publisher Copyright: © 2023 The Author(s)

PY - 2023/12/15

Y1 - 2023/12/15

N2 - Conventional recording neural electrodes are made of stiff materials such as metal or silicon which triggers unwanted inflammation and does not provide intimate contact with brain tissue. Flexible neural electrodes have therefore been increasingly investigated to address these issues. In this study, we introduce reduced graphene oxide (rGO) recording electrodes in the format of 3-dimensional flexible membranes (rGO-3D) and 2-dimensional thin films (rGO-2D) for long-term and acute recordings, respectively. The rGO electrodes supported the functional development of cultured primary neurons and displayed good recording capabilities similar to conventional glass pipette and Pt ball electrodes in ex vivo and acute in vivo experiments. In vivo biocompatibility studies demonstrated the migration of neural processes onto the rGO-2D surface and within the rGO-3D electrodes, with the latter forming an intimate interpenetrating network. This study not only generates new knowledge to balance conductivity and porosity of rGO coatings but also provides in-depth evaluation of the physical and biological properties of such interfaces.

AB - Conventional recording neural electrodes are made of stiff materials such as metal or silicon which triggers unwanted inflammation and does not provide intimate contact with brain tissue. Flexible neural electrodes have therefore been increasingly investigated to address these issues. In this study, we introduce reduced graphene oxide (rGO) recording electrodes in the format of 3-dimensional flexible membranes (rGO-3D) and 2-dimensional thin films (rGO-2D) for long-term and acute recordings, respectively. The rGO electrodes supported the functional development of cultured primary neurons and displayed good recording capabilities similar to conventional glass pipette and Pt ball electrodes in ex vivo and acute in vivo experiments. In vivo biocompatibility studies demonstrated the migration of neural processes onto the rGO-2D surface and within the rGO-3D electrodes, with the latter forming an intimate interpenetrating network. This study not only generates new knowledge to balance conductivity and porosity of rGO coatings but also provides in-depth evaluation of the physical and biological properties of such interfaces.

KW - Flexible neural electrodes

KW - Neural electrodes

KW - Recording neural electrodes

KW - Reduced graphene oxide

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DO - 10.1016/j.cej.2023.147067

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SN - 1385-8947

VL - 478

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

M1 - 147067

ER -

Flexible neural recording electrodes based on reduced graphene oxide interfaces

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Keywords

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ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D)

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Flexible neural recording electrodes based on reduced graphene oxide interfaces

Abstract

Keywords

Access to Document

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ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D)

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