Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents

Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen, Colin Clyne

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

Original languageEnglish
Pages (from-to)3434-3446
Number of pages13
JournalCurrent Medicinal Chemistry
Volume22
Issue number30
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • Breast cancer
  • Chemopreventive agents
  • Chemotherapeutic agents
  • Flavonoids

Cite this

Nde, C. B. M., Zingue, S., Winter, E., Creczynski-Pasa, T. B., Michel, T., Fernandez, X., Njamen, D., & Clyne, C. (2015). Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents. Current Medicinal Chemistry, 22(30), 3434-3446. https://doi.org/10.2174/0929867322666150729115321