Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents

Chantal Beatrice Magne Nde; Stephane Zingue; Evelyn Winter; Tania Beatriz Creczynski-Pasa; Thomas Michel; Xavier Fernandez; Dieudonne Njamen; Colin Clyne

doi:10.2174/0929867322666150729115321

Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents

Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen, Colin Clyne

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

Original language	English
Pages (from-to)	3434-3446
Number of pages	13
Journal	Current Medicinal Chemistry
Volume	22
Issue number	30
DOIs	https://doi.org/10.2174/0929867322666150729115321
Publication status	Published - 1 Nov 2015

Keywords

Breast cancer
Chemopreventive agents
Chemotherapeutic agents
Flavonoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/0929867322666150729115321

Cite this

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abstract = "Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.",

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T1 - Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents

AU - Nde, Chantal Beatrice Magne

AU - Zingue, Stephane

AU - Winter, Evelyn

AU - Creczynski-Pasa, Tania Beatriz

AU - Michel, Thomas

AU - Fernandez, Xavier

AU - Njamen, Dieudonne

AU - Clyne, Colin

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

AB - Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

KW - Breast cancer

KW - Chemopreventive agents

KW - Chemotherapeutic agents

KW - Flavonoids

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DO - 10.2174/0929867322666150729115321

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Flavonoids, breast cancer chemopreventive and/or chemotherapeutic agents

Abstract

Keywords

UN SDGs

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