Flavonoid identification and hypoglycaemic studies of the butanol fraction from Gynura procumbens

G. A. Akowuah; A. Sadikun; A. Mariam

doi:10.1076/phbi.40.6.405.8440

Flavonoid identification and hypoglycaemic studies of the butanol fraction from Gynura procumbens

G. A. Akowuah, A. Sadikun, A. Mariam

Research output: Contribution to journal › Article › Research › peer-review

92 Citations (Scopus)

Abstract

The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n-butanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.

Original language	English
Pages (from-to)	405-410
Number of pages	6
Journal	Pharmaceutical Biology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1076/phbi.40.6.405.8440
Publication status	Published - Sept 2002
Externally published	Yes

Keywords

Compositae
Flavonoid glycoside
Glibenclamide
Kaempferol
Quercetin
Streptozotocin

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1076/phbi.40.6.405.8440

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abstract = "The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n-butanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.",

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AU - Akowuah, G. A.

AU - Sadikun, A.

AU - Mariam, A.

PY - 2002/9

Y1 - 2002/9

N2 - The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n-butanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.

AB - The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n-butanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.

KW - Compositae

KW - Flavonoid glycoside

KW - Glibenclamide

KW - Kaempferol

KW - Quercetin

KW - Streptozotocin

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SN - 1388-0209

VL - 40

SP - 405

EP - 410

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 6

ER -

Flavonoid identification and hypoglycaemic studies of the butanol fraction from Gynura procumbens

Abstract

Keywords

UN SDGs

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