Five years of letrozole compared with tamoxifen as initial adjuvant thrapy for postmenopausal women with endocrine-responsive early breast cancer update of study BIG 1-98

Alan S Coates, Aparna Keshaviah, Beat Thurlimann, Henning Mouridsen, Louis Mauriac, John F Forbes, Robert Paridaens, Monica Castiglione-Gertsch, Richard D Gelber, Marco Colleoni, Istvan Lang, Lucia Del Mastro, Ian Smith, Jacquie Chirgwin, Jean-Marie Nogaret, Tadeusz Pienkowski, Andrew Wardley, Erik H Jakobsen, Karen N Price, Aron Goldhirsch

Research output: Contribution to journalArticleResearchpeer-review


Previous analyses of the Breast International Group (BIG) 1-98 four-arm study compared initial therapy with letrozole or tamoxifen including patients randomly assigned to sequential treatment whose information was censored at the time of therapy change. Because this presentation may unduly reflect early events, the present analysis is limited to patients randomly assigned to the continuous therapy arms and includes protocol-defined updated results
Original languageEnglish
Pages (from-to)486 - 492
Number of pages7
JournalJournal of Clinical Oncology
Issue number5
Publication statusPublished - 2007

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