First trimester biomarkers in the prediction of later pregnancy complications

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly "high risk" population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.

Original languageEnglish
Article number807196
Number of pages6
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

Cite this

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title = "First trimester biomarkers in the prediction of later pregnancy complications",
abstract = "Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly {"}high risk{"} population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.",
author = "Kane, {Stefan C.} and {da Silva Costa}, Fabricio and Shaun Brennecke",
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language = "English",
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First trimester biomarkers in the prediction of later pregnancy complications. / Kane, Stefan C.; da Silva Costa, Fabricio; Brennecke, Shaun.

In: BioMed Research International, Vol. 2014, 807196, 2014.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - First trimester biomarkers in the prediction of later pregnancy complications

AU - Kane, Stefan C.

AU - da Silva Costa, Fabricio

AU - Brennecke, Shaun

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AB - Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly "high risk" population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.

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DO - 10.1155/2014/807196

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VL - 2014

JO - BioMed Research International

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