First total synthesis of14C-labeled procyanidin B2 - A milestone toward understanding cocoa polyphenol metabolism

Florian Viton, Cyrille Landreau, David Rustidge, Fabien Robert, Gary Williamson, Denis Barron

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)


The idea that foods consumed for pure pleasure could provide health benefits received much recognition in the recent years. Among these foods, cocoa and dark chocolate are particularly rich in procyanidins, one of the major dietary families of polyphenols. We developed the first asymmetric total synthesis of procyanidin B2 and applied it to the preparation of a regioselectively radiolabeled 14C-analogue, which will be used to strengthen our knowledge on the metabolism of procyanidins.

Original languageEnglish
Pages (from-to)6069-6078
Number of pages10
JournalEuropean Journal of Organic Chemistry
Issue number36
Publication statusPublished - 1 Dec 2008
Externally publishedYes


  • Natural products
  • Polyphenols
  • Radiochemistry
  • Total synthesis

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