First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)

Diletta Bianchini; Aurelius Omlin; Carmel Jo Pezaro; David Lorente; Roberta Ferraldeschi; Deborah Mukherji; Mateus Crespo; Ines Figueiredo; Susana Miranda; Ruth Riisnaes; Andrea Zivi; Aby Buchbinder; Dana E Rathkopf; Gerhardt Attard; Howard I Scher; Johann S De Bono; Daniel C Danila

doi:10.1038/bjc.2013.619

First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)

Diletta Bianchini, Aurelius Omlin, Carmel Jo Pezaro, David Lorente, Roberta Ferraldeschi, Deborah Mukherji, Mateus Crespo, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Andrea Zivi, Aby Buchbinder, Dana E Rathkopf, Gerhardt Attard, Howard I Scher, Johann S De Bono, Daniel C Danila

Research output: Contribution to journal › Article › Research › peer-review

54 Citations (Scopus)

Original language	English
Pages (from-to)	2579 - 2586
Number of pages	8
Journal	British Journal of Cancer
Volume	109
Issue number	10
DOIs	https://doi.org/10.1038/bjc.2013.619
Publication status	Published - 2013
Externally published	Yes

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Bianchini, D., Omlin, A., Pezaro, C. J., Lorente, D., Ferraldeschi, R., Mukherji, D., Crespo, M., Figueiredo, I., Miranda, S., Riisnaes, R., Zivi, A., Buchbinder, A., Rathkopf, D. E., Attard, G., Scher, H. I., De Bono, J. S., & Danila, D. C. (2013). First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC). British Journal of Cancer, 109(10), 2579 - 2586. https://doi.org/10.1038/bjc.2013.619

Bianchini, Diletta ; Omlin, Aurelius ; Pezaro, Carmel Jo ; Lorente, David ; Ferraldeschi, Roberta ; Mukherji, Deborah ; Crespo, Mateus ; Figueiredo, Ines ; Miranda, Susana ; Riisnaes, Ruth ; Zivi, Andrea ; Buchbinder, Aby ; Rathkopf, Dana E ; Attard, Gerhardt ; Scher, Howard I ; De Bono, Johann S ; Danila, Daniel C. / First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC). In: British Journal of Cancer. 2013 ; Vol. 109, No. 10. pp. 2579 - 2586.

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title = "First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)",

author = "Diletta Bianchini and Aurelius Omlin and Pezaro, {Carmel Jo} and David Lorente and Roberta Ferraldeschi and Deborah Mukherji and Mateus Crespo and Ines Figueiredo and Susana Miranda and Ruth Riisnaes and Andrea Zivi and Aby Buchbinder and Rathkopf, {Dana E} and Gerhardt Attard and Scher, {Howard I} and {De Bono}, {Johann S} and Danila, {Daniel C}",

year = "2013",

doi = "10.1038/bjc.2013.619",

language = "English",

volume = "109",

pages = "2579 -- 2586",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

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Bianchini, D, Omlin, A, Pezaro, CJ, Lorente, D, Ferraldeschi, R, Mukherji, D, Crespo, M, Figueiredo, I, Miranda, S, Riisnaes, R, Zivi, A, Buchbinder, A, Rathkopf, DE, Attard, G, Scher, HI, De Bono, JS & Danila, DC 2013, 'First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)', British Journal of Cancer, vol. 109, no. 10, pp. 2579 - 2586. https://doi.org/10.1038/bjc.2013.619

First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC). / Bianchini, Diletta; Omlin, Aurelius; Pezaro, Carmel Jo; Lorente, David; Ferraldeschi, Roberta; Mukherji, Deborah; Crespo, Mateus; Figueiredo, Ines; Miranda, Susana; Riisnaes, Ruth; Zivi, Andrea; Buchbinder, Aby; Rathkopf, Dana E; Attard, Gerhardt; Scher, Howard I; De Bono, Johann S; Danila, Daniel C.

In: British Journal of Cancer, Vol. 109, No. 10, 2013, p. 2579 - 2586.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - First-in-human Phase I study of EZN-4176, a locked antisense oligonucleotide (LNA-ASO) to exon 4 of the androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC)

AU - Bianchini, Diletta

AU - Omlin, Aurelius

AU - Pezaro, Carmel Jo

AU - Lorente, David

AU - Ferraldeschi, Roberta

AU - Mukherji, Deborah

AU - Crespo, Mateus

AU - Figueiredo, Ines

AU - Miranda, Susana

AU - Riisnaes, Ruth

AU - Zivi, Andrea

AU - Buchbinder, Aby

AU - Rathkopf, Dana E

AU - Attard, Gerhardt

AU - Scher, Howard I

AU - De Bono, Johann S

AU - Danila, Daniel C

PY - 2013

Y1 - 2013

UR - http://www.nature.com/bjc/journal/v109/n10/pdf/bjc2013619a.pdf

U2 - 10.1038/bjc.2013.619

DO - 10.1038/bjc.2013.619

M3 - Article

VL - 109

SP - 2579

EP - 2586

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 10

ER -