Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo

Li Yan, Zhigang Wang, Xianfeng Chen, Xiao Jun Gou, Zhenyu Zhang, Xiaoyue Zhu, Minhuan Lan, Wei Chen, Guangyu Zhu, Wenjun Zhang

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

In using nanomaterials for advanced photodynamic therapy, it is important to improve surface modification to increase stability, minimize non-specific loss of drugs in blood circulation, enhance the photostability of photosensitizers, and achieve highly efficient intracellular uptake. In this report, we for the first time covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes. These nanoflakes display many superior characteristics and lead to excellent in vivo photodynamic therapeutic efficiency and safety profiles.

Original languageEnglish
Pages (from-to)2339-2342
Number of pages4
JournalChemical Communications
Volume53
Issue number15
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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