Fibromyalgia is a common and disabling condition. It has enormous impact on the individual, their family, the community and society as a whole. Fibromyalgia is characterized by widespread, chronic musculoskeletal pain and tenderness. Other symptoms include fatigue, sleep disorders, cognitive disturbance, and high levels of distress. It is often associated with regional pain problems such as recurrent headache, irritable bowel syndrome or temporomandibular joint disorder, and is commonly found in people with affective or anxiety disorders. Fibromyalgia can occur alone, or in conjunction with other longstanding illness, including endocrine and connective tissue disorders. The pathological mechanisms, predisposing elements, and triggering factors are becoming well-defined. There are now clearly understood tenets for management of this condition. These include the importance of a multidisciplinary approach in all cases and patient education as the foundation for any management strategy. Pharmacological therapies are currently being used to effectively target different mechanistic problems in fibromyalgia. Nonpharmacological measures should be used in conjunction with drugs, including graded intensity, low-impact aerobic exercise and psychological approaches such as cognitive behavioral therapy (CBT).