Fibrinogen diagnostics in major hemorrhage

Marek Bialkower, Gil Garnier

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


Fibrinogen is one of the first factors to fall to critically low levels in the blood in many coagulopathic events. Patients with hypofibrinogenemia are at a significantly greater risk of major hemorrhage and death. The rapid replacement of fibrinogen early on in hypofibrinogenemia may significantly improve outcomes for patients. Fibrinogen is present at concentrations between 2 and 4 g/L in the plasma of healthy people. However, hypofibrinogenemia is diagnosed when the fibrinogen level drops below 1.5–2 g/L. This review analyses different types of fibrinogen assays that can be used for diagnosing hypofibrinogenemia. The scientific mechanisms and limitations behind these tests are then presented. Additionally, the current state of clinical major hemorrhage protocols (MHPs) is presented and the structure, function and physiological role of fibrinogen is summarized.

Original languageEnglish
Pages (from-to)194-209
Number of pages16
JournalCritical Reviews in Analytical Chemistry
Issue number1
Publication statusPublished - 2022


  • Blood
  • coagulopathy
  • fibrinogen concentration
  • fibrinogen diagnostic
  • major hemorrhage
  • transfusion

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