@article{28c53a7a305b4dc082165be24f214a3b,
title = "Fiber-Specific Measures of White Matter Microstructure and Macrostructure Are Associated With Internalizing and Externalizing Symptoms in Children Born Very Preterm and Full-term",
abstract = "Background: Tensor-based investigations suggest that delayed or disrupted white matter development may relate to adverse behavioral outcomes in individuals born very preterm (VP); however, metrics derived from such models lack specificity. Here, we applied a fixel-based analysis framework to examine white matter microstructural and macrostructural correlates of concurrent internalizing and externalizing problems in VP and full-term (FT) children at 7 and 13 years. Methods: Diffusion imaging data were collected in a longitudinal cohort of VP and FT individuals (130 VP and 29 FT at 7 years, 125 VP and 44 FT at 13 years). Fixel-based measures of fiber density, fiber-bundle cross-section, and fiber density and cross-section were extracted from 21 white matter tracts previously implicated in psychopathology. Internalizing and externalizing symptoms were assessed using the Strengths and Difficulties Questionnaire parent report at 7 and 13 years. Results: At age 7 years, widespread reductions in fiber-bundle cross-section and fiber density and cross-section and tract-specific reductions in fiber density were related to more internalizing and externalizing symptoms irrespective of birth group. At age 13 years, fixel-based measures were not related to internalizing symptoms, while tract-specific reductions in fiber density, fiber-bundle cross-section, and fiber density and cross-section measures were related to more externalizing symptoms in the FT group only. Conclusions: Age-specific neurobiological markers of internalizing and externalizing problems identified in this study extend previous tensor-based findings to inform pathophysiological models of behavior problems and provide the foundation for investigations into novel preventative and therapeutic interventions to mitigate risk in VP and other high-risk infant populations.",
keywords = "Adolescence, Childhood, Fixel-based analysis, Magnetic resonance imaging, Premature birth, Psychopathology",
author = "Gilchrist, {Courtney P.} and Kelly, {Claire E.} and Angela Cumberland and Thijs Dhollander and Karli Treyvaud and Katherine Lee and Cheong, {Jeanie L.Y.} and Doyle, {Lex W.} and Inder, {Terrie E.} and Thompson, {Deanne K.} and Mary Tolcos and Anderson, {Peter J.}",
note = "Funding Information: This study was supported in part by an Australian Government Research Training Program Scholarship (to CPG and CK); the Australian National Health and Medical Research Council (Center for Clinical Research Excellence (Grant Nos. 546519, 1060733, and 1153176); Project Grant (Grant Nos. 237117, 491209, and 1066555); Career Development Fellowships 1085754 and 1160003 [to DKT] and 1141354 [to JLYC]; Early Career Fellowship 1012236 [to DKT]; and Senior Research Fellowship 1081288 and Leadership Fellowship 1176077 [to PJA]); Financial Markets Foundation for Children Project Grant (Grant No. 2019-083 [to AC, PJA, DKT, MT]); RMIT Vice Chancellor{\textquoteright}s Senior Research Fellowship and Australian Research Council Future Fellowship (to MT); U.S. National Institutes of Health (Grant No. HD058056); Murdoch Children{\textquoteright}s Research Institute; the Royal Children{\textquoteright}s Hospital; The Royal Children{\textquoteright}s Hospital Foundation; Department of Paediatrics, The University of Melbourne; and the Victorian Government{\textquoteright}s Operational Infrastructure Support Program. Funding Information: This study was supported in part by an Australian Government Research Training Program Scholarship (to CPG and CK); the Australian National Health and Medical Research Council (Center for Clinical Research Excellence (Grant Nos. 546519, 1060733, and 1153176); Project Grant (Grant Nos. 237117, 491209, and 1066555); Career Development Fellowships 1085754 and 1160003 [to DKT] and 1141354 [to JLYC]; Early Career Fellowship 1012236 [to DKT]; and Senior Research Fellowship 1081288 and Leadership Fellowship 1176077 [to PJA]); Financial Markets Foundation for Children Project Grant (Grant No. 2019-083 [to AC, PJA, DKT, MT]); RMIT Vice Chancellor's Senior Research Fellowship and Australian Research Council Future Fellowship (to MT); U.S. National Institutes of Health (Grant No. HD058056); Murdoch Children's Research Institute; the Royal Children's Hospital; The Royal Children's Hospital Foundation; Department of Paediatrics, The University of Melbourne; and the Victorian Government's Operational Infrastructure Support Program. CPG, CEK, AC, TD, KT, KL, JLYC, LWD, DKT, TEI, MT, and PJA have made substantial contributions to the design of this study and to the editing of this manuscript. CPG conducted data analysis and interpretation and prepared the initial manuscript draft. KL provided statistical consultation. All authors approve the submitted version and agree to be accountable for all aspects of the work. We acknowledge the contributions of the Victorian Infant Brain Studies and Developmental Imaging groups at the Murdoch Children's Research Institute and Michael Kean and radiographers at the Royal Children's Hospital for the magnetic resonance images. We thank the families involved in this study. The authors report no biomedical financial interests or potential conflicts of interest. Publisher Copyright: {\textcopyright} 2022 Society of Biological Psychiatry",
year = "2023",
month = mar,
day = "15",
doi = "10.1016/j.biopsych.2022.09.011",
language = "English",
volume = "93",
pages = "575--585",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "6",
}