FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo

Hitomi Kurose, Mayumi Okamoto, Miyuki Shimizu, Takaaki Bito, Christophe Marcelle, Sumihare Noji, Hideyo Ohuchi

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The fibroblast growth factor (FGF) family is known to be involved in vertebrate eye development. However, distinct roles of individual FGF members during eye development remain largely elusive. Here, we show a detailed expression pattern of Fgf19 in chick lens development. Fgf19 expression initiated in the forebrain, and then became restricted to the distal portion of the optic vesicle abutting the future lens placode, where FGF receptor 4 (Fgfr4), a receptor for FGF19, was expressed. Fgf8, a positive regulator for L-Maf, was expressed in a portion of the optic vesicle. To examine the role of FGF19 signaling during early eye development, Fgf19 was misexpressed near the presumptive lens ectoderm; however, no alteration in the expression of lens marker genes was observed. Conversely, a secreted form of FGFR4 was misexpressed to inhibit an FGF19 signal, resulting in the induction of L-Maf expression. To further define the relationship between L-Maf and Fgf19, L-Maf misexpression was performed, resulting in ectopic induction of Fgf19 expression by Hamburger and Hamilton s stage 12/13. Furthermore, misexpression of Fgf8 induced Fgf19 expression in addition to L-Maf. These results suggest that FGF19-FGFR4 signaling plays a role in early lens development in collaboration with FGF8 signaling and L-Maf transcriptional system.
Original languageEnglish
Pages (from-to)213 - 223
Number of pages11
JournalDevelopment Growth & Differentiation
Volume47
Issue number4
Publication statusPublished - 2005

Cite this

Kurose, H., Okamoto, M., Shimizu, M., Bito, T., Marcelle, C., Noji, S., & Ohuchi, H. (2005). FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo. Development Growth & Differentiation, 47(4), 213 - 223.
Kurose, Hitomi ; Okamoto, Mayumi ; Shimizu, Miyuki ; Bito, Takaaki ; Marcelle, Christophe ; Noji, Sumihare ; Ohuchi, Hideyo. / FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo. In: Development Growth & Differentiation. 2005 ; Vol. 47, No. 4. pp. 213 - 223.
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abstract = "The fibroblast growth factor (FGF) family is known to be involved in vertebrate eye development. However, distinct roles of individual FGF members during eye development remain largely elusive. Here, we show a detailed expression pattern of Fgf19 in chick lens development. Fgf19 expression initiated in the forebrain, and then became restricted to the distal portion of the optic vesicle abutting the future lens placode, where FGF receptor 4 (Fgfr4), a receptor for FGF19, was expressed. Fgf8, a positive regulator for L-Maf, was expressed in a portion of the optic vesicle. To examine the role of FGF19 signaling during early eye development, Fgf19 was misexpressed near the presumptive lens ectoderm; however, no alteration in the expression of lens marker genes was observed. Conversely, a secreted form of FGFR4 was misexpressed to inhibit an FGF19 signal, resulting in the induction of L-Maf expression. To further define the relationship between L-Maf and Fgf19, L-Maf misexpression was performed, resulting in ectopic induction of Fgf19 expression by Hamburger and Hamilton s stage 12/13. Furthermore, misexpression of Fgf8 induced Fgf19 expression in addition to L-Maf. These results suggest that FGF19-FGFR4 signaling plays a role in early lens development in collaboration with FGF8 signaling and L-Maf transcriptional system.",
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Kurose, H, Okamoto, M, Shimizu, M, Bito, T, Marcelle, C, Noji, S & Ohuchi, H 2005, 'FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo' Development Growth & Differentiation, vol. 47, no. 4, pp. 213 - 223.

FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo. / Kurose, Hitomi; Okamoto, Mayumi; Shimizu, Miyuki; Bito, Takaaki; Marcelle, Christophe; Noji, Sumihare; Ohuchi, Hideyo.

In: Development Growth & Differentiation, Vol. 47, No. 4, 2005, p. 213 - 223.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - FGF19-FGFR4 signaling elaborates lens induction with the FGF8-L-Maf cascade in the chick embryo

AU - Kurose, Hitomi

AU - Okamoto, Mayumi

AU - Shimizu, Miyuki

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AU - Marcelle, Christophe

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AU - Ohuchi, Hideyo

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AB - The fibroblast growth factor (FGF) family is known to be involved in vertebrate eye development. However, distinct roles of individual FGF members during eye development remain largely elusive. Here, we show a detailed expression pattern of Fgf19 in chick lens development. Fgf19 expression initiated in the forebrain, and then became restricted to the distal portion of the optic vesicle abutting the future lens placode, where FGF receptor 4 (Fgfr4), a receptor for FGF19, was expressed. Fgf8, a positive regulator for L-Maf, was expressed in a portion of the optic vesicle. To examine the role of FGF19 signaling during early eye development, Fgf19 was misexpressed near the presumptive lens ectoderm; however, no alteration in the expression of lens marker genes was observed. Conversely, a secreted form of FGFR4 was misexpressed to inhibit an FGF19 signal, resulting in the induction of L-Maf expression. To further define the relationship between L-Maf and Fgf19, L-Maf misexpression was performed, resulting in ectopic induction of Fgf19 expression by Hamburger and Hamilton s stage 12/13. Furthermore, misexpression of Fgf8 induced Fgf19 expression in addition to L-Maf. These results suggest that FGF19-FGFR4 signaling plays a role in early lens development in collaboration with FGF8 signaling and L-Maf transcriptional system.

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