FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

D. Agarwal; Sandy S Pineda; Kyriaki Michailidou; Jesús Herranz; Gabriel Pita; Laura T. Moreno-Moyano; M. Rosario Alonso; John Dennis; Q. Wang; Manjeet K. Bolla; K. B. Meyer; P. Menéndez-Rodríguez; David Hardisson; Marta Mendiola; A. González-Neira; Annika Lindblom; Sara Margolin; Anthony J Swerdlow; Alan Ashworth; N. Orr; M. Jones; Kosuke Matsuo; Hiroshi Ito; Hiroji Iwata; Naomi Kondo; kConFab Investigators; Australian Ovarian Cancer Study Group (AOCS); Jacob M Hartman; Mun Hui; W. Y. Lim; Philip Tsau-Choong Iau; Edward Sawyer; Ian P Tomlinson; Michael Kerin; N. Miller; Deying Kang; J. Y. Choi; Sarah S Park; Dong-Young Noh; J. L. Hopper; D. F. Schmidt; E. Makalic; M.C. Southey; S. H. Teo; C. H. Yip; Kavitta Sivanandan; Wan Ting Tay; Hiltrud Brauch; T. Brüning; Ute Hamann; The GENICA Network; A. M. Dunning; Ajay M Shah; Irene L Andrulis; J. A. Knight; Grodon Glendon; Srine Tchatchou; Annegien Broeks; E. H. Rosenberg; Laura J. Van't Veer; Peter A. Fasching; Stefan P Renner; Arif B Ekici; Matthias W. Beckmann; Yu-chi Shen; Chia-Ni Hsiung; J. C. Yu; Ming-Feng Hou; William Blot; Qian Cai; A. H. Wu; Chiu-Chen Tseng; Christine D Berg; Daniel O Stram; A. Cox; Ian W. Brock; M. W.R. Reed; Keith Muir; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; W H Zheng; Sandra Deming-Halverson; Matha J. Shrubsole; J. Long; Xiao-Ou Shu; W. Lu; Y. T. Gao; B. Zhang; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Frederique Mariette; Suleeporn Sangrajrang; J. McKay; Fergus J Couch; Amanda E. Toland; Drakoulis Yannoukakos; Olivia Fletcher; N. Johnson; I. Dos Santos Silva; Julian Peto; Frederik Marme; Barbara Burwinkel; P. Guénel; T. Truong; M Sanchez; Claire Mulot; Stig E Bojesen; Børge G. Nordestgaard; H. Flyer; Hermann Brenner; Aida K.arina Dieffenbach; Volker Arndt; Christa Stegmaier; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Diether Lambrechts; Betul T. Yesilyurt; Giuseppe Floris; Karin Leunen; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; X. Wang; Janet E Olson; Celine M Vachon; Kristen S. Purrington; G.G. Giles; Gianluca Severi; Laura Baglietto; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Jacques Simard; L M Dumont; M. S. Goldberg; F. Labrèche; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Peter Devilee; R. A. E M Tollenaar; Caroline Seynaeve; M. García-Closas; Stephen J Chanock; Jolanta Lissowska; Jonine D Figueroa; Kamila Czene; M. Eriksson; Keith Humphreys; Hatef Darabi; Maartje J Hooning; Mieke Kriege; J. M. Collée; Madeleine M A Tilanus-Linthorst; J. Li; Anna Jakubowska; Mark J Lubinski; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Heli Nevanlinna; Taru A. Muranen; Kristiina Aittomäki; Carl Blomqvist; Natalia Bogdanova; Dörk Thilo Dörk; Georgia Chenevix-Trench; P. Hall; Douglas F Easton; P. D. P Pharoah; J. I. Arias-Perez; Pilar Zamora; J. Benítez; R.L. Milne

doi:10.1038/bjc.2013.769

FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

D. Agarwal, Sandy S Pineda, Kyriaki Michailidou, Jesús Herranz, Gabriel Pita, Laura T. Moreno-Moyano, M. Rosario Alonso, John Dennis, Q. Wang, Manjeet K. Bolla, K. B. Meyer, P. Menéndez-Rodríguez, David Hardisson, Marta Mendiola, A. González-Neira, Annika Lindblom, Sara Margolin, Anthony J Swerdlow, Alan Ashworth, N. OrrM. Jones, Kosuke Matsuo, Hiroshi Ito, Hiroji Iwata, Naomi Kondo, kConFab Investigators, Australian Ovarian Cancer Study Group (AOCS), Jacob M Hartman, Mun Hui, W. Y. Lim, Philip Tsau-Choong Iau, Edward Sawyer, Ian P Tomlinson, Michael Kerin, N. Miller, Deying Kang, J. Y. Choi, Sarah S Park, Dong-Young Noh, J. L. Hopper, D. F. Schmidt, E. Makalic, M.C. Southey, S. H. Teo, C. H. Yip, Kavitta Sivanandan, Wan Ting Tay, Hiltrud Brauch, T. Brüning, Ute Hamann, The GENICA Network, A. M. Dunning, Ajay M Shah, Irene L Andrulis, J. A. Knight, Grodon Glendon, Srine Tchatchou, Annegien Broeks, E. H. Rosenberg, Laura J. Van't Veer, Peter A. Fasching, Stefan P Renner, Arif B Ekici, Matthias W. Beckmann, Yu-chi Shen, Chia-Ni Hsiung, J. C. Yu, Ming-Feng Hou, William Blot, Qian Cai, A. H. Wu, Chiu-Chen Tseng, Christine D Berg, Daniel O Stram, A. Cox, Ian W. Brock, M. W.R. Reed, Keith Muir, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, W H Zheng, Sandra Deming-Halverson, Matha J. Shrubsole, J. Long, Xiao-Ou Shu, W. Lu, Y. T. Gao, B. Zhang, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Frederique Mariette, Suleeporn Sangrajrang, J. McKay, Fergus J Couch, Amanda E. Toland, Drakoulis Yannoukakos, Olivia Fletcher, N. Johnson, I. Dos Santos Silva, Julian Peto, Frederik Marme, Barbara Burwinkel, P. Guénel, T. Truong, M Sanchez, Claire Mulot, Stig E Bojesen, Børge G. Nordestgaard, H. Flyer, Hermann Brenner, Aida K.arina Dieffenbach, Volker Arndt, Christa Stegmaier, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Diether Lambrechts, Betul T. Yesilyurt, Giuseppe Floris, Karin Leunen, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, X. Wang, Janet E Olson, Celine M Vachon, Kristen S. Purrington, G.G. Giles, Gianluca Severi, Laura Baglietto, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Jacques Simard, L M Dumont, M. S. Goldberg, F. Labrèche, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Peter Devilee, R. A. E M Tollenaar, Caroline Seynaeve, M. García-Closas, Stephen J Chanock, Jolanta Lissowska, Jonine D Figueroa, Kamila Czene, M. Eriksson, Keith Humphreys, Hatef Darabi, Maartje J Hooning, Mieke Kriege, J. M. Collée, Madeleine M A Tilanus-Linthorst, J. Li, Anna Jakubowska, Mark J Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Heli Nevanlinna, Taru A. Muranen, Kristiina Aittomäki, Carl Blomqvist, Natalia Bogdanova, Dörk Thilo Dörk, Georgia Chenevix-Trench, P. Hall, Douglas F Easton, P. D. P Pharoah, J. I. Arias-Perez, Pilar Zamora, J. Benítez, R.L. Milne

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

Original language	English
Pages (from-to)	1088-1100
Number of pages	13
Journal	British Journal of Cancer
Volume	110
Issue number	4
DOIs	https://doi.org/10.1038/bjc.2013.769
Publication status	Published - 18 Feb 2014
Externally published	Yes

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125492947-oaFinal published version, 291 KBLicence: CC BY-NC

Cite this

Agarwal, D., Pineda, S. S., Michailidou, K., Herranz, J., Pita, G., Moreno-Moyano, L. T., Alonso, M. R., Dennis, J., Wang, Q., Bolla, M. K., Meyer, K. B., Menéndez-Rodríguez, P., Hardisson, D., Mendiola, M., González-Neira, A., Lindblom, A., Margolin, S., Swerdlow, A. J., Ashworth, A., ... Milne, R. L. (2014). FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium. British Journal of Cancer, 110(4), 1088-1100. https://doi.org/10.1038/bjc.2013.769

@article{fe99b612f40341f4a95dce3de7b1857c,

title = "FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium",

abstract = "Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.",

author = "D. Agarwal and Pineda, {Sandy S} and Kyriaki Michailidou and Jes{\'u}s Herranz and Gabriel Pita and Moreno-Moyano, {Laura T.} and Alonso, {M. Rosario} and John Dennis and Q. Wang and Bolla, {Manjeet K.} and Meyer, {K. B.} and P. Men{\'e}ndez-Rodr{\'i}guez and David Hardisson and Marta Mendiola and A. Gonz{\'a}lez-Neira and Annika Lindblom and Sara Margolin and Swerdlow, {Anthony J} and Alan Ashworth and N. Orr and M. Jones and Kosuke Matsuo and Hiroshi Ito and Hiroji Iwata and Naomi Kondo and {kConFab Investigators} and {Australian Ovarian Cancer Study Group (AOCS)} and Hartman, {Jacob M} and Mun Hui and Lim, {W. Y.} and Iau, {Philip Tsau-Choong} and Edward Sawyer and Tomlinson, {Ian P} and Michael Kerin and N. Miller and Deying Kang and Choi, {J. Y.} and Park, {Sarah S} and Dong-Young Noh and Hopper, {J. L.} and Schmidt, {D. F.} and E. Makalic and M.C. Southey and Teo, {S. H.} and Yip, {C. H.} and Kavitta Sivanandan and Tay, {Wan Ting} and Hiltrud Brauch and T. Br{\"u}ning and Ute Hamann and {The GENICA Network} and Dunning, {A. M.} and Shah, {Ajay M} and Andrulis, {Irene L} and Knight, {J. A.} and Grodon Glendon and Srine Tchatchou and Annegien Broeks and Rosenberg, {E. H.} and {Van't Veer}, {Laura J.} and Fasching, {Peter A.} and Renner, {Stefan P} and Ekici, {Arif B} and Beckmann, {Matthias W.} and Yu-chi Shen and Chia-Ni Hsiung and Yu, {J. C.} and Ming-Feng Hou and William Blot and Qian Cai and Wu, {A. H.} and Chiu-Chen Tseng and Berg, {Christine D} and Stram, {Daniel O} and A. Cox and Brock, {Ian W.} and Reed, {M. W.R.} and Keith Muir and Artitaya Lophatananon and Sarah Stewart-Brown and Pornthep Siriwanarangsan and Zheng, {W H} and Sandra Deming-Halverson and Shrubsole, {Matha J.} and J. Long and Xiao-Ou Shu and W. Lu and Gao, {Y. T.} and B. Zhang and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Frederique Mariette and Suleeporn Sangrajrang and J. McKay and Couch, {Fergus J} and Toland, {Amanda E.} and Drakoulis Yannoukakos and Olivia Fletcher and N. Johnson and {Dos Santos Silva}, I. and Julian Peto and Frederik Marme and Barbara Burwinkel and P. Gu{\'e}nel and T. Truong and M Sanchez and Claire Mulot and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G.} and H. Flyer and Hermann Brenner and Dieffenbach, {Aida K.arina} and Volker Arndt and Christa Stegmaier and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, {Jaana M.} and Diether Lambrechts and Yesilyurt, {Betul T.} and Giuseppe Floris and Karin Leunen and Jenny Chang-Claude and Anja Rudolph and Petra Seibold and Dieter Flesch-Janys and X. Wang and Olson, {Janet E} and Vachon, {Celine M} and Purrington, {Kristen S.} and G.G. Giles and Gianluca Severi and Laura Baglietto and Haiman, {Christopher A} and Henderson, {Brian E} and Fredrick Schumacher and {Le Marchand}, Loic and Jacques Simard and Dumont, {L M} and Goldberg, {M. S.} and F. Labr{\`e}che and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Peter Devilee and {E M Tollenaar}, {R. A.} and Caroline Seynaeve and M. Garc{\'i}a-Closas and Chanock, {Stephen J} and Jolanta Lissowska and Figueroa, {Jonine D} and Kamila Czene and M. Eriksson and Keith Humphreys and Hatef Darabi and Hooning, {Maartje J} and Mieke Kriege and Coll{\'e}e, {J. M.} and Tilanus-Linthorst, {Madeleine M A} and J. Li and Anna Jakubowska and Lubinski, {Mark J} and Katarzyna Jaworska-Bieniek and Katarzyna Durda and Heli Nevanlinna and Muranen, {Taru A.} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Natalia Bogdanova and {Thilo D{\"o}rk}, D{\"o}rk and Georgia Chenevix-Trench and P. Hall and Easton, {Douglas F} and {P Pharoah}, {P. D.} and Arias-Perez, {J. I.} and Pilar Zamora and J. Ben{\'i}tez and R.L. Milne",

year = "2014",

month = feb,

day = "18",

doi = "10.1038/bjc.2013.769",

language = "English",

volume = "110",

pages = "1088--1100",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "4",

}

Agarwal, D, Pineda, SS, Michailidou, K, Herranz, J, Pita, G, Moreno-Moyano, LT, Alonso, MR, Dennis, J, Wang, Q, Bolla, MK, Meyer, KB, Menéndez-Rodríguez, P, Hardisson, D, Mendiola, M, González-Neira, A, Lindblom, A, Margolin, S, Swerdlow, AJ, Ashworth, A, Orr, N, Jones, M, Matsuo, K, Ito, H, Iwata, H, Kondo, N, kConFab Investigators, Australian Ovarian Cancer Study Group (AOCS), Hartman, JM, Hui, M, Lim, WY, Iau, PT-C, Sawyer, E, Tomlinson, IP, Kerin, M, Miller, N, Kang, D, Choi, JY, Park, SS, Noh, D-Y, Hopper, JL, Schmidt, DF , Makalic, E , Southey, MC, Teo, SH, Yip, CH, Sivanandan, K, Tay, WT, Brauch, H, Brüning, T, Hamann, U, The GENICA Network, Dunning, AM, Shah, AM, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Broeks, A, Rosenberg, EH, Van't Veer, LJ, Fasching, PA, Renner, SP, Ekici, AB, Beckmann, MW, Shen, Y, Hsiung, C-N, Yu, JC, Hou, M-F, Blot, W, Cai, Q, Wu, AH, Tseng, C-C, Berg, CD, Stram, DO, Cox, A, Brock, IW, Reed, MWR, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Zheng, WH, Deming-Halverson, S, Shrubsole, MJ, Long, J, Shu, X-O, Lu, W, Gao, YT, Zhang, B, Radice, P, Peterlongo, P, Manoukian, S, Mariette, F, Sangrajrang, S, McKay, J, Couch, FJ, Toland, AE, Yannoukakos, D, Fletcher, O, Johnson, N, Dos Santos Silva, I, Peto, J, Marme, F, Burwinkel, B, Guénel, P, Truong, T, Sanchez, M, Mulot, C, Bojesen, SE, Nordestgaard, BG, Flyer, H, Brenner, H, Dieffenbach, AKA, Arndt, V, Stegmaier, C, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Lambrechts, D, Yesilyurt, BT, Floris, G, Leunen, K, Chang-Claude, J, Rudolph, A, Seibold, P, Flesch-Janys, D, Wang, X, Olson, JE, Vachon, CM, Purrington, KS, Giles, GG, Severi, G, Baglietto, L, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Simard, J, Dumont, LM, Goldberg, MS, Labrèche, F, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Devilee, P, E M Tollenaar, RA, Seynaeve, C, García-Closas, M, Chanock, SJ, Lissowska, J, Figueroa, JD, Czene, K, Eriksson, M, Humphreys, K, Darabi, H, Hooning, MJ, Kriege, M, Collée, JM, Tilanus-Linthorst, MMA, Li, J, Jakubowska, A, Lubinski, MJ, Jaworska-Bieniek, K, Durda, K, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Bogdanova, N, Thilo Dörk, D, Chenevix-Trench, G, Hall, P, Easton, DF, P Pharoah, PD, Arias-Perez, JI, Zamora, P, Benítez, J & Milne, RL 2014, 'FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium', British Journal of Cancer, vol. 110, no. 4, pp. 1088-1100. https://doi.org/10.1038/bjc.2013.769

TY - JOUR

T1 - FGF receptor genes and breast cancer susceptibility

T2 - Results from the Breast Cancer Association Consortium

AU - Agarwal, D.

AU - Pineda, Sandy S

AU - Michailidou, Kyriaki

AU - Herranz, Jesús

AU - Pita, Gabriel

AU - Moreno-Moyano, Laura T.

AU - Alonso, M. Rosario

AU - Dennis, John

AU - Wang, Q.

AU - Bolla, Manjeet K.

AU - Meyer, K. B.

AU - Menéndez-Rodríguez, P.

AU - Hardisson, David

AU - Mendiola, Marta

AU - González-Neira, A.

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Swerdlow, Anthony J

AU - Ashworth, Alan

AU - Orr, N.

AU - Jones, M.

AU - Matsuo, Kosuke

AU - Ito, Hiroshi

AU - Iwata, Hiroji

AU - Kondo, Naomi

AU - kConFab Investigators

AU - Australian Ovarian Cancer Study Group (AOCS)

AU - Hartman, Jacob M

AU - Hui, Mun

AU - Lim, W. Y.

AU - Iau, Philip Tsau-Choong

AU - Sawyer, Edward

AU - Tomlinson, Ian P

AU - Kerin, Michael

AU - Miller, N.

AU - Kang, Deying

AU - Choi, J. Y.

AU - Park, Sarah S

AU - Noh, Dong-Young

AU - Hopper, J. L.

AU - Schmidt, D. F.

AU - Makalic, E.

AU - Southey, M.C.

AU - Teo, S. H.

AU - Yip, C. H.

AU - Sivanandan, Kavitta

AU - Tay, Wan Ting

AU - Brauch, Hiltrud

AU - Brüning, T.

AU - Hamann, Ute

AU - The GENICA Network

AU - Dunning, A. M.

AU - Shah, Ajay M

AU - Andrulis, Irene L

AU - Knight, J. A.

AU - Glendon, Grodon

AU - Tchatchou, Srine

AU - Broeks, Annegien

AU - Rosenberg, E. H.

AU - Van't Veer, Laura J.

AU - Fasching, Peter A.

AU - Renner, Stefan P

AU - Ekici, Arif B

AU - Beckmann, Matthias W.

AU - Shen, Yu-chi

AU - Hsiung, Chia-Ni

AU - Yu, J. C.

AU - Hou, Ming-Feng

AU - Blot, William

AU - Cai, Qian

AU - Wu, A. H.

AU - Tseng, Chiu-Chen

AU - Berg, Christine D

AU - Stram, Daniel O

AU - Cox, A.

AU - Brock, Ian W.

AU - Reed, M. W.R.

AU - Muir, Keith

AU - Lophatananon, Artitaya

AU - Stewart-Brown, Sarah

AU - Siriwanarangsan, Pornthep

AU - Zheng, W H

AU - Deming-Halverson, Sandra

AU - Shrubsole, Matha J.

AU - Long, J.

AU - Shu, Xiao-Ou

AU - Lu, W.

AU - Gao, Y. T.

AU - Zhang, B.

AU - Radice, Paolo

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Mariette, Frederique

AU - Sangrajrang, Suleeporn

AU - McKay, J.

AU - Couch, Fergus J

AU - Toland, Amanda E.

AU - Yannoukakos, Drakoulis

AU - Fletcher, Olivia

AU - Johnson, N.

AU - Dos Santos Silva, I.

AU - Peto, Julian

AU - Marme, Frederik

AU - Burwinkel, Barbara

AU - Guénel, P.

AU - Truong, T.

AU - Sanchez, M

AU - Mulot, Claire

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G.

AU - Flyer, H.

AU - Brenner, Hermann

AU - Dieffenbach, Aida K.arina

AU - Arndt, Volker

AU - Stegmaier, Christa

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M.

AU - Lambrechts, Diether

AU - Yesilyurt, Betul T.

AU - Floris, Giuseppe

AU - Leunen, Karin

AU - Chang-Claude, Jenny

AU - Rudolph, Anja

AU - Seibold, Petra

AU - Flesch-Janys, Dieter

AU - Wang, X.

AU - Olson, Janet E

AU - Vachon, Celine M

AU - Purrington, Kristen S.

AU - Giles, G.G.

AU - Severi, Gianluca

AU - Baglietto, Laura

AU - Haiman, Christopher A

AU - Henderson, Brian E

AU - Schumacher, Fredrick

AU - Le Marchand, Loic

AU - Simard, Jacques

AU - Dumont, L M

AU - Goldberg, M. S.

AU - Labrèche, F.

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Devilee, Peter

AU - E M Tollenaar, R. A.

AU - Seynaeve, Caroline

AU - García-Closas, M.

AU - Chanock, Stephen J

AU - Lissowska, Jolanta

AU - Figueroa, Jonine D

AU - Czene, Kamila

AU - Eriksson, M.

AU - Humphreys, Keith

AU - Darabi, Hatef

AU - Hooning, Maartje J

AU - Kriege, Mieke

AU - Collée, J. M.

AU - Tilanus-Linthorst, Madeleine M A

AU - Li, J.

AU - Jakubowska, Anna

AU - Lubinski, Mark J

AU - Jaworska-Bieniek, Katarzyna

AU - Durda, Katarzyna

AU - Nevanlinna, Heli

AU - Muranen, Taru A.

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Bogdanova, Natalia

AU - Thilo Dörk, Dörk

AU - Chenevix-Trench, Georgia

AU - Hall, P.

AU - Easton, Douglas F

AU - P Pharoah, P. D.

AU - Arias-Perez, J. I.

AU - Zamora, Pilar

AU - Benítez, J.

AU - Milne, R.L.

PY - 2014/2/18

Y1 - 2014/2/18

N2 - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

AB - Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

UR - http://www.scopus.com/inward/record.url?scp=84894304619&partnerID=8YFLogxK

U2 - 10.1038/bjc.2013.769

DO - 10.1038/bjc.2013.769

M3 - Article

C2 - 24548884

AN - SCOPUS:84894304619

SN - 0007-0920

VL - 110

SP - 1088

EP - 1100

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -

FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

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