Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish

Yona Goldshmit, Tamar E Sztal, Patricia R Jusuf, Thomas E Hall, Mai Eva Nguyen Chi, Peter D Currie

Research output: Contribution to journalArticleResearchpeer-review

180 Citations (Scopus)


Adult zebrafish show a remarkable capacity to regenerate their spinal column after injury, an ability that stands in stark contrast to the limited repair that occurs within the mammalian CNS post-injury. The reasons for this interspecies difference in regenerative capacity remain unclear. Here we demonstrate a novel role for Fgf signaling during glial cell morphogenesis in promoting axonal regeneration after spinal cord injury. Zebrafish glia are induced by Fgf signaling, to form an elongated bipolar morphology that forms a bridge between the two sides of the resected spinal cord, over which regenerating axons actively migrate. Loss of Fgf function inhibits formation of this glial bridge and prevents axon regeneration. Despite the poor potential for mammalian axonal regeneration, primate astrocytes activated by Fgf signaling adopt a similar morphology to that induced in zebrafish glia. This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury.
Original languageEnglish
Pages (from-to)7477 - 7492
Number of pages16
JournalJournal of Neuroscience
Issue number22
Publication statusPublished - 2012

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