Fever in sepsis: Is it cool to be hot?

Paul Young, Rinaldo Bellomo

Research output: Contribution to journalLetterOther

25 Citations (Scopus)


Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infection associated with very high mortality. Combined with recent data suggesting that febrile patients with infections have the lowest mortality risk, the study raises the question of whether inducing therapeutic hyperthermia might be beneficial in this patient group. Body temperature is easily measured and manipulated in the ICU, and interventional trials defining the most appropriate temperature targets in ICU patients with infections are urgently needed. One such study is in progress.
Original languageEnglish
Pages (from-to)109 - 115
Number of pages7
JournalCritical Care
Issue number1
Publication statusPublished - 2014

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