Fetal HPA activation, preterm birth and postnatal programming

Deborah M Sloboda, Timothy Moss, John Newnham, John Challis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)


This volume examines the role of steroids and peptides in the regulation of pregnancy and pregnancy outcome, and their long-term effects including possible influences on adult-onset diseases. During pregnancy the placenta acts as a central regulator and coordinator of maternal and fetal physiology, and the onset of labor, through its production and regulation of steroids and peptides. Perturbations to this regulatory system can result in poor pregnancy outcome, such as preterm birth and low birth weight. These in turn are linked to diseases in later life. Intriguingly, many of these regulatory actions of steroids and peptides also occur in the brain. The induction and suppression of peptides by steroids appears to be key to regulatory function in both brain and placenta. These various interweaving strands, linking basic science with obstetrics, are all reviewed in depth here producing a fascinating account of an important area of materno-fetal medicine.
Original languageEnglish
Title of host publicationBirth, Distress and Disease: Placental-Brain Interactions
EditorsMichael L Power, Jay Schulkin
Place of PublicationUnited Kingdom
PublisherCambridge University Press
Pages114 - 141
Number of pages28
ISBN (Print)9780521831482
Publication statusPublished - 2005
Externally publishedYes

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