Fetal brain injury in complicated monochorionic pregnancies: diagnostic yield of prenatal MRI following surveillance ultrasound and influence on prognostic counselling

Alice Robinson, Mark Teoh, Andrew Edwards, Michael Fahey, Stacy Goergen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: This study aimed to determine the additional diagnostic information provided by prenatal (fetal) magnetic resonance imaging (pMRI) following tertiary ultrasound (US) for fetal cranial abnormalities in complicated monochorionic gestations. Methods: Women with complicated monochorionic gestations complicated by twin–twin transfusion syndrome, co-twin demise (CD), selective intrauterine growth restriction, and/or twin anaemia–polycythaemia sequence who were referred for pMRI after tertiary US were included. Additional diagnostic information by pMRI that changed prognostic counselling was the primary outcome. Results: Thirty-three women with 48 live fetuses had pMRI at a median of 25 weeks (range: 21–29). Three of ten survivors of spontaneous CD, one of eight survivors of CD after twin–twin transfusion syndrome and 1/30 co-survivors had diagnostic information added by pMRI that altered counselling; US was normal in two and in the other three underrepresented parenchymal injury (5/33 = 15%; 95% confidence interval ±0.27–0.03). Additional findings included occipital lobe infarction, hemispheric injury, dural sinus thrombosis, ischaemia-producing polymicrogyria and intraventricular haemorrhage. Another 8/33 women had additional information provided by pMRI that did not alter counselling. Conclusion: Prenatal magnetic resonance imaging resulted in changed prognostic counselling in 5/33 pregnancies. Evaluation of incorporation of pMRI into routine surveillance of complicated monochorionic gestations is needed.

Original languageEnglish
Pages (from-to)611-627
Number of pages17
JournalPrenatal Diagnosis
Volume37
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Cite this

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title = "Fetal brain injury in complicated monochorionic pregnancies: diagnostic yield of prenatal MRI following surveillance ultrasound and influence on prognostic counselling",
abstract = "Objective: This study aimed to determine the additional diagnostic information provided by prenatal (fetal) magnetic resonance imaging (pMRI) following tertiary ultrasound (US) for fetal cranial abnormalities in complicated monochorionic gestations. Methods: Women with complicated monochorionic gestations complicated by twin–twin transfusion syndrome, co-twin demise (CD), selective intrauterine growth restriction, and/or twin anaemia–polycythaemia sequence who were referred for pMRI after tertiary US were included. Additional diagnostic information by pMRI that changed prognostic counselling was the primary outcome. Results: Thirty-three women with 48 live fetuses had pMRI at a median of 25 weeks (range: 21–29). Three of ten survivors of spontaneous CD, one of eight survivors of CD after twin–twin transfusion syndrome and 1/30 co-survivors had diagnostic information added by pMRI that altered counselling; US was normal in two and in the other three underrepresented parenchymal injury (5/33 = 15{\%}; 95{\%} confidence interval ±0.27–0.03). Additional findings included occipital lobe infarction, hemispheric injury, dural sinus thrombosis, ischaemia-producing polymicrogyria and intraventricular haemorrhage. Another 8/33 women had additional information provided by pMRI that did not alter counselling. Conclusion: Prenatal magnetic resonance imaging resulted in changed prognostic counselling in 5/33 pregnancies. Evaluation of incorporation of pMRI into routine surveillance of complicated monochorionic gestations is needed.",
author = "Alice Robinson and Mark Teoh and Andrew Edwards and Michael Fahey and Stacy Goergen",
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Fetal brain injury in complicated monochorionic pregnancies : diagnostic yield of prenatal MRI following surveillance ultrasound and influence on prognostic counselling. / Robinson, Alice; Teoh, Mark; Edwards, Andrew; Fahey, Michael; Goergen, Stacy.

In: Prenatal Diagnosis, Vol. 37, No. 6, 01.06.2017, p. 611-627.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Fetal brain injury in complicated monochorionic pregnancies

T2 - diagnostic yield of prenatal MRI following surveillance ultrasound and influence on prognostic counselling

AU - Robinson, Alice

AU - Teoh, Mark

AU - Edwards, Andrew

AU - Fahey, Michael

AU - Goergen, Stacy

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N2 - Objective: This study aimed to determine the additional diagnostic information provided by prenatal (fetal) magnetic resonance imaging (pMRI) following tertiary ultrasound (US) for fetal cranial abnormalities in complicated monochorionic gestations. Methods: Women with complicated monochorionic gestations complicated by twin–twin transfusion syndrome, co-twin demise (CD), selective intrauterine growth restriction, and/or twin anaemia–polycythaemia sequence who were referred for pMRI after tertiary US were included. Additional diagnostic information by pMRI that changed prognostic counselling was the primary outcome. Results: Thirty-three women with 48 live fetuses had pMRI at a median of 25 weeks (range: 21–29). Three of ten survivors of spontaneous CD, one of eight survivors of CD after twin–twin transfusion syndrome and 1/30 co-survivors had diagnostic information added by pMRI that altered counselling; US was normal in two and in the other three underrepresented parenchymal injury (5/33 = 15%; 95% confidence interval ±0.27–0.03). Additional findings included occipital lobe infarction, hemispheric injury, dural sinus thrombosis, ischaemia-producing polymicrogyria and intraventricular haemorrhage. Another 8/33 women had additional information provided by pMRI that did not alter counselling. Conclusion: Prenatal magnetic resonance imaging resulted in changed prognostic counselling in 5/33 pregnancies. Evaluation of incorporation of pMRI into routine surveillance of complicated monochorionic gestations is needed.

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