Fertility and obstetric outcomes after curettage versus expectant management in randomised and non-randomised women with an incomplete evacuation of the uterus after misoprostol treatment for miscarriage

M. Lemmers, M. A.C. Verschoor, K. Overwater, P. M. Bossuyt, D. Hendriks, M. Hemelaar, J. M. Schutte, A. H. Adriaanse, W. M. Ankum, J. A.F. Huirne, B. W.J. Mol

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Objective To assess fertility and obstetric outcomes in women treated with curettage or undergoing expectant management for an incomplete miscarriage after misoprostol treatment. Study Design Between June 2012 and July 2014, we conducted a multicentre randomised clinical trial (RCT) with a parallel cohort study for non-randomised women, treated according to their preference. In the RCT 30 women were allocated curettage and 29 expectant management. In the cohort 197 women participated; 65 underwent curettage and 132 women underwent expectant management. Primary outcome was curation, defined as either an empty uterus on sonography at six weeks or an uneventful clinical follow-up. We used questionnaires to assess fertility and obstetric outcome of the first new pregnancy subsequent to study enrolment. Results Curation was seen in 91/95 women treated with curettage (95.8%) versus 134/161 women managed expectantly (83.2%) (p = 0.003). The response rate was 211/255 (82%). In 198 women pursuing a new pregnancy, conception rates were 92% (67/73) in the curettage group versus 96% (120/125) in the expectant management group (OR 0.96, 95% CI 0.89;1.03, p = 0.34), with ongoing pregnancy rates of 87% (58/67) versus 78% (94/120), respectively (OR 1.12, 95% CI 0.99;1.28, p = 0.226). Preterm birth rates were 1/46 in the curettage group versus 8/81 in the expectant management group (OR 0.22, 95% CI 0.03;1.71 P = 0.15). Caesarean section rates were 23% and 24% for women in the curettage group and expectant management group respectively. Conclusion In women with an incomplete evacuation of the uterus after misoprostol treatment, curettage and expectant management does not lead to different fertility and pregnancy outcomes, as compared to expectant management.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Publication statusPublished - 1 Apr 2017
Externally publishedYes


  • Curettage
  • Fertility
  • Incomplete evacuation
  • Miscarriage
  • Misoprostol
  • Obstetric outcome

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