TY - JOUR
T1 - Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma
AU - Amukotuwa, Shalini A.
AU - Choong, Peter F.M.
AU - Smith, Peter J.
AU - Powell, Gerard J.
AU - Thomas, David
AU - Schlicht, Stephen M.
PY - 2006/5
Y1 - 2006/5
N2 - Mesenchymal chondrosarcoma is a rare but aggressive, high-grade malignancy of primitive cartilage-forming mesenchyme that arises most commonly from skeletal sites. Although there are radiological findings suggestive of the diagnosis, imaging features often overlap with those of other skeletal sarcomas. The definitive diagnosis relies on the histological finding of a typical bimorphic appearance, consisting of nests of small, round, poorly differentiated cells and more mature cartilaginous tissue. To highlight this, we present the case of a 21-year-old man who was referred to our institution with a history of right knee pain. Initial imaging and histological evaluation of a core biopsy of the lesion suggested osteosarcoma of the distal right femur; after review, however, the correct diagnosis of mesenchymal chondrosarcoma was made. Adequate tissue sampling and thorough histological evaluation of biopsy specimens is vital for the accurate diagnosis of primary bone malignancies, especially those of chondroid origin.
AB - Mesenchymal chondrosarcoma is a rare but aggressive, high-grade malignancy of primitive cartilage-forming mesenchyme that arises most commonly from skeletal sites. Although there are radiological findings suggestive of the diagnosis, imaging features often overlap with those of other skeletal sarcomas. The definitive diagnosis relies on the histological finding of a typical bimorphic appearance, consisting of nests of small, round, poorly differentiated cells and more mature cartilaginous tissue. To highlight this, we present the case of a 21-year-old man who was referred to our institution with a history of right knee pain. Initial imaging and histological evaluation of a core biopsy of the lesion suggested osteosarcoma of the distal right femur; after review, however, the correct diagnosis of mesenchymal chondrosarcoma was made. Adequate tissue sampling and thorough histological evaluation of biopsy specimens is vital for the accurate diagnosis of primary bone malignancies, especially those of chondroid origin.
KW - Femur
KW - Mesenchymal chondrosarcoma
KW - MRI
KW - Secondary aneurysmal bone cyst
KW - Small cell osteosarcoma
UR - http://www.scopus.com/inward/record.url?scp=33645469615&partnerID=8YFLogxK
U2 - 10.1007/s00256-005-0044-6
DO - 10.1007/s00256-005-0044-6
M3 - Review Article
C2 - 16328381
AN - SCOPUS:33645469615
VL - 35
SP - 311
EP - 318
JO - Skeletal Radiology
JF - Skeletal Radiology
SN - 0364-2348
IS - 5
ER -