Abstract
Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.
| Original language | English |
|---|---|
| Pages (from-to) | 1051-1053 |
| Number of pages | 3 |
| Journal | Cell |
| Volume | 139 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 11 Dec 2009 |
| Externally published | Yes |
Cite this
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Females Battle to Suppress Their Inner Male. / Sinclair, Andrew; Smith, Craig.
In: Cell, Vol. 139, No. 6, 11.12.2009, p. 1051-1053.Research output: Contribution to journal › Short Survey › Research › peer-review
TY - JOUR
T1 - Females Battle to Suppress Their Inner Male
AU - Sinclair, Andrew
AU - Smith, Craig
PY - 2009/12/11
Y1 - 2009/12/11
N2 - Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.
AB - Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.
UR - http://www.scopus.com/inward/record.url?scp=71149084102&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2009.11.036
DO - 10.1016/j.cell.2009.11.036
M3 - Short Survey
VL - 139
SP - 1051
EP - 1053
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -