Females Battle to Suppress Their Inner Male

Andrew Sinclair; Craig Smith

doi:10.1016/j.cell.2009.11.036

Females Battle to Suppress Their Inner Male

Andrew Sinclair, Craig Smith

Research output: Contribution to journal › Short Survey › Research › peer-review

13 Citations (Scopus)

Abstract

Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

Original language	English
Pages (from-to)	1051-1053
Number of pages	3
Journal	Cell
Volume	139
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2009.11.036
Publication status	Published - 11 Dec 2009
Externally published	Yes

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10.1016/j.cell.2009.11.036

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title = "Females Battle to Suppress Their Inner Male",

abstract = "Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.",

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AU - Smith, Craig

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AB - Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

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M3 - Short Survey

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JO - Cell

JF - Cell

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Females Battle to Suppress Their Inner Male

Abstract

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