Females Battle to Suppress Their Inner Male

Andrew Sinclair, Craig Smith

Research output: Contribution to journalShort SurveyResearchpeer-review

11 Citations (Scopus)

Abstract

Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

Original languageEnglish
Pages (from-to)1051-1053
Number of pages3
JournalCell
Volume139
Issue number6
DOIs
Publication statusPublished - 11 Dec 2009
Externally publishedYes

Cite this

Sinclair, Andrew ; Smith, Craig. / Females Battle to Suppress Their Inner Male. In: Cell. 2009 ; Vol. 139, No. 6. pp. 1051-1053.
@article{a37213389c004261ac46f99bd7f2fc6f,
title = "Females Battle to Suppress Their Inner Male",
abstract = "Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.",
author = "Andrew Sinclair and Craig Smith",
year = "2009",
month = "12",
day = "11",
doi = "10.1016/j.cell.2009.11.036",
language = "English",
volume = "139",
pages = "1051--1053",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier",
number = "6",

}

Females Battle to Suppress Their Inner Male. / Sinclair, Andrew; Smith, Craig.

In: Cell, Vol. 139, No. 6, 11.12.2009, p. 1051-1053.

Research output: Contribution to journalShort SurveyResearchpeer-review

TY - JOUR

T1 - Females Battle to Suppress Their Inner Male

AU - Sinclair, Andrew

AU - Smith, Craig

PY - 2009/12/11

Y1 - 2009/12/11

N2 - Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

AB - Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.

UR - http://www.scopus.com/inward/record.url?scp=71149084102&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2009.11.036

DO - 10.1016/j.cell.2009.11.036

M3 - Short Survey

VL - 139

SP - 1051

EP - 1053

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -