Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms

Shyr-Yen Lin, Rebecca Georgette Craythorn, Anne O'Connor, Martin M Matzuk, Jane Eleanor Girling, John Roderick Morrison, David Morritz de Kretser

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

The circulating and tissue-bound forms of follistatin (FST315 and FST288, respectively) modulate the actions of activins. FST knockout (KO/null) mice, lacking both isoforms, die perinatally with defects in lung, skin, and the musculoskeletal system. Using constructs of the human FST gene engineered to enable expression of each isoform under the control of natural regulatory elements, transgenic mouse lines were created and crossed with FST null mice to attempt to rescue the neonatal lethality.........
Original languageEnglish
Pages (from-to)415 - 429
Number of pages14
JournalMolecular Endocrinology
Volume22
Issue numberepub ahead of print
Publication statusPublished - 2008

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