Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution

Jarrod Andrew Dudakov; Danika Mei Po Khong; Richard Lennox Boyd; Ann Patricia Chidgey

doi:10.1016/j.it.2010.02.002

Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution

Jarrod Andrew Dudakov
, Danika Mei Po Khong
, Richard Lennox Boyd
, Ann Patricia Chidgey

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest lymphoid progenitors that leave the bone marrow and seed the thymus. Hematopoiesis is effectively continuous throughout life, but there is a profound decline in immune function with increasing age, driven by thymus involution and severely curtailed B cell development. A key question is whether defects in bone marrow progenitors, such as reduced differentiation and repopulation potential, are the common denominator. While thymic involution temporally precedes overt HSC functional decline, a logical supposition is that the latter exacerbates the former. This review explores this possible link, and concludes that improving bone marrow function is fundamental to sustained thymic regeneration.

Original language	English
Pages (from-to)	191 - 198
Number of pages	8
Journal	Trends in Immunology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.it.2010.02.002
Publication status	Published - 2010

Access to Document

10.1016/j.it.2010.02.002

Cite this

@article{bd351dab4864415ea83316e1a8d12976,

title = "Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution",

abstract = "Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest lymphoid progenitors that leave the bone marrow and seed the thymus. Hematopoiesis is effectively continuous throughout life, but there is a profound decline in immune function with increasing age, driven by thymus involution and severely curtailed B cell development. A key question is whether defects in bone marrow progenitors, such as reduced differentiation and repopulation potential, are the common denominator. While thymic involution temporally precedes overt HSC functional decline, a logical supposition is that the latter exacerbates the former. This review explores this possible link, and concludes that improving bone marrow function is fundamental to sustained thymic regeneration.",

author = "Dudakov, \{Jarrod Andrew\} and Khong, \{Danika Mei Po\} and Boyd, \{Richard Lennox\} and Chidgey, \{Ann Patricia\}",

year = "2010",

doi = "10.1016/j.it.2010.02.002",

language = "English",

volume = "31",

pages = "191 -- 198",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution

AU - Dudakov, Jarrod Andrew

AU - Khong, Danika Mei Po

AU - Boyd, Richard Lennox

AU - Chidgey, Ann Patricia

PY - 2010

Y1 - 2010

N2 - Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest lymphoid progenitors that leave the bone marrow and seed the thymus. Hematopoiesis is effectively continuous throughout life, but there is a profound decline in immune function with increasing age, driven by thymus involution and severely curtailed B cell development. A key question is whether defects in bone marrow progenitors, such as reduced differentiation and repopulation potential, are the common denominator. While thymic involution temporally precedes overt HSC functional decline, a logical supposition is that the latter exacerbates the former. This review explores this possible link, and concludes that improving bone marrow function is fundamental to sustained thymic regeneration.

AB - Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest lymphoid progenitors that leave the bone marrow and seed the thymus. Hematopoiesis is effectively continuous throughout life, but there is a profound decline in immune function with increasing age, driven by thymus involution and severely curtailed B cell development. A key question is whether defects in bone marrow progenitors, such as reduced differentiation and repopulation potential, are the common denominator. While thymic involution temporally precedes overt HSC functional decline, a logical supposition is that the latter exacerbates the former. This review explores this possible link, and concludes that improving bone marrow function is fundamental to sustained thymic regeneration.

UR - http://www.ncbi.nlm.nih.gov/pubmed/20356793

U2 - 10.1016/j.it.2010.02.002

DO - 10.1016/j.it.2010.02.002

M3 - Article

SN - 1471-4906

VL - 31

SP - 191

EP - 198

JO - Trends in Immunology

JF - Trends in Immunology

IS - 5

ER -

Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution

Abstract

Access to Document

Other files and links

Cite this