Feedback Regulation of Thyrotropin Secretion by Thyroid Hormones

Richard E. Kleinmann, Lewis E. Braverman, P. J. Fuller, J. R. Stockigt, P. Reed Larsen

Research output: Contribution to journalLetterOtherpeer-review

6 Citations (Scopus)


To the Editor: In his Seminar in Medicine in the January 7 issue, Larsen states that iopanoic acid probably has an in portant effect on intrapituitary conversion of thyroxine (T4) to triiodothyronine (T3), since T3 replacement in a small group of normal subjects who had received iopanoic acid did not normalize the response of thyroid-stimulating hormone (TSH) to thyrotropin-releasing hormone (TRH).1 He cites a study of ours2 as the reference for this statement. However, in our study, T3 replacement in subjects who had received iopanoic acid did normalize the TSH response to TRH. Subjects.

Original languageEnglish
Pages (from-to)1236-1237
Number of pages2
JournalThe New England Journal of Medicine
Issue number20
Publication statusPublished - 20 May 1982
Externally publishedYes

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