TY - JOUR
T1 - Feedback Regulation by Inhibins A and B of the Pituitary Secretion of Follicle-Stimulating Hormone
AU - Makanji, Yogeshwar
AU - Harrison, Craig A.
AU - Robertson, David M.
PY - 2011
Y1 - 2011
N2 - Inhibins A and B are gonadal factors that negatively regulate FSH synthesis by the anterior pituitary. Across the menstrual cycle, women show a strong inverse correlation between circulating FSH and inhibin B, estradiol, and anti-Mullerian hormone (AMH), but not with inhibin A. Estradiol is believed to provide a tonic inhibitory effect while the inhibitory role of AMH is unknown. In human males, inhibin B is the primary testicular factor regulating FSH with limited effects by gonadal steroids. In vitro and in vivo studies in rats indicate that inhibin B is more biologically active than inhibin A but showed a lower affinity for the activin type II receptors and the co-receptor, betaglycan, suggesting an alternative mechanism. While this review reinforces the important role inhibin plays in regulating FSH, the observed differences in mode of action of inhibins A and B and their interplay with other gonadal factors are still poorly understood.
AB - Inhibins A and B are gonadal factors that negatively regulate FSH synthesis by the anterior pituitary. Across the menstrual cycle, women show a strong inverse correlation between circulating FSH and inhibin B, estradiol, and anti-Mullerian hormone (AMH), but not with inhibin A. Estradiol is believed to provide a tonic inhibitory effect while the inhibitory role of AMH is unknown. In human males, inhibin B is the primary testicular factor regulating FSH with limited effects by gonadal steroids. In vitro and in vivo studies in rats indicate that inhibin B is more biologically active than inhibin A but showed a lower affinity for the activin type II receptors and the co-receptor, betaglycan, suggesting an alternative mechanism. While this review reinforces the important role inhibin plays in regulating FSH, the observed differences in mode of action of inhibins A and B and their interplay with other gonadal factors are still poorly understood.
KW - Activin type II receptors
KW - Betaglycan
KW - Bioactivity
KW - Glycosylation
KW - LH
UR - http://www.scopus.com/inward/record.url?scp=79951904504&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-385961-7.00014-7
DO - 10.1016/B978-0-12-385961-7.00014-7
M3 - Article
C2 - 21353886
AN - SCOPUS:79951904504
SN - 0083-6729
VL - 85
SP - 299
EP - 321
JO - Vitamins and Hormones-Advances in Research and Applications
JF - Vitamins and Hormones-Advances in Research and Applications
ER -