Feasibility of a chronic, minimally invasive endovascular neural interface

Nicholas L. Opie, Gil S. Rind, Sam E. John, Stephen M. Ronayne, David B. Grayden, Anthony N. Burkitt, Clive N. May, Terence J. O'Brien, Thomas J. Oxley

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

9 Citations (Scopus)

Abstract

Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall. Baseline neural recording were used to identify the maximum bandwidth of the neural interface, which remained stable around 193 Hz for six months. Cross-sectional areas of the implanted vessels were non-destructively measured using the Australian Synchrotron. There was no case of occlusion observed in any of the implanted animals. This work demonstrates the feasibility of an endovascular neural interface to safely and efficaciously record neural information over a chronic time course.

Original languageEnglish
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2016)
EditorsJose Principe, Jose Carmena, Justin Sanchez
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages4455-4458
Number of pages4
ISBN (Electronic)9781457702204
ISBN (Print)9781457702198
DOIs
Publication statusPublished - 2016
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2016 - Walt Disney World Resort, Orlando, United States of America
Duration: 16 Aug 201620 Aug 2016
Conference number: 38th
https://embc.embs.org/2016/
https://ieeexplore.ieee.org/xpl/conhome/7580725/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2016
Abbreviated titleEMBC 2016
CountryUnited States of America
CityOrlando
Period16/08/1620/08/16
Internet address

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