@article{9941c2b743aa4291af1c00d9fae82c13,
title = "Feasibility and acceptability of targeted salivary cytomegalovirus screening through universal newborn hearing screening",
abstract = "Aim: This study aimed to determine the feasibility and parental acceptability of screening for congenital cytomegalovirus (cCMV) through saliva polymerase chain reaction in infants who did not pass their newborn hearing screening. Additionally, the utility (i.e. time to diagnosis and treatment) of this enhanced clinical pathway was evaluated. Methods: The study was conducted through the Victorian Infant Hearing Screening Programme (VIHSP) across four maternity hospitals in Melbourne, Australia, during June 2019–March 2020. Parents were approached by VIHSP staff about obtaining a test for cytomegalovirus (CMV) at the time of their baby's second positive ({\textquoteleft}refer{\textquoteright}) result on the VIHSP screen. Participating parents collected a saliva swab for CMV polymerase chain reaction from their infants. Feasibility was determined by the proportion of {\textquoteleft}referred{\textquoteright} infants whose parents completed the salivary CMV screening test ≤21 days of life. Acceptability was measured through parent survey. Results: Of 126 eligible families, 96 (76.0\%) had salivary screening swabs taken ≤21 days of life. Most families (>92.0\%) indicated that screening was acceptable, straightforward and thought testing their baby for cCMV was a good idea. One infant screened positive on day 30, was diagnosed with cCMV via confirmatory testing by day 31 and commenced valganciclovir on day 32. Conclusions: Obtaining a saliva sample to screen for cCMV in infants who do not pass their newborn hearing screen is feasible and appears acceptable to parents. This targeted cCMV screening method could be an option where mothers are rapidly discharged from hospital, especially in the context of the COVID-19 pandemic.",
keywords = "congenital cytomegalovirus, feasibility, hearing loss, targeted screening",
author = "Emma Webb and Gillespie, \{Alanna N.\} and Zeffie Poulakis and Tim Gartland and Jim Buttery and Dan Casalaz and Daley, \{Andrew J.\} and Susan Donath and Amanda Gwee and Jacobs, \{Susan E.\} and Phuong, \{Linny K.\} and Rosalynn Pszczola and Rachael Purcell and Kerryn Saunders and Seilesh Kadambari and Jones, \{Cheryl A.\} and Valerie Sung and Melinda Barker and David Burgner and Julia Clark and Costa, \{Anna Maria\} and Michelle Giles and Bron Hennebry and Alice Stewart and \{the HearS-cCMV Study Team\}",
note = "Funding Information: The study was funded by the University of Melbourne Stevenson Chair of Paediatrics Strategic Support 2017–2018. Saliva PCR costs for each site were funded by a 2018 Mercy Hospitals Victoria Limited Small Research Grant, Mercy Hospital for Women small grant and Monash Health Immunisation Research Grant. Research at the Murdoch Children's Research Institute is supported by the Victorian government's Operational Infrastructure Support Programme. The researchers were independent of the funders. E Webb was supported by a Deafness Foundation PhD Scholarship. V Sung was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (1125687), a Melbourne Children's Clinician Scientist Fellowship 2021 and a L'Or{\'e}al‐UNESCO Australian and New Zealand for Women in Science Fellowship 2019. A Gwee was supported by a University of Melbourne Melbourne Medical School Strategic Grant for Outstanding Women, a Melbourne Children{\textquoteright}s Campus Clinician‐Scientist Fellowship and a National Health and Medical Research Council Investigator grant GNT1194694. The authors thank the Royal Children's Hospital's Victorian Infant Hearing Screening Programme Screeners, Area Managers, Senior Area Managers, Early Support Services and administrative team, as well as the midwives and paediatric staff at the Mercy Hospital for Women, Joan Kirner's Women's and Children's Hospital, Monash Health and Royal Women's Hospital. Special thanks to all participating families, and to Janet Burgess, Amanda Di Carlo and Greg Waller for facilitating laboratory testing at the Royal Children's Hospital. Publisher Copyright: {\textcopyright} 2021 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).",
year = "2022",
month = feb,
doi = "10.1111/jpc.15705",
language = "English",
volume = "58",
pages = "288--294",
journal = "Journal of Paediatrics and Child Health",
issn = "1034-4810",
publisher = "Wiley-Blackwell",
number = "2",
}