Fear conditioning, safety learning, and sleep in humans

Anisa J Marshall, Dean T Acheson, Victoria B Risbrough, Laura D Straus, Sean P.A. Drummond

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Fear conditioning is considered an animal model of post-traumatic stress disorder. Such models have shown fear conditioning disrupts subsequent rapid eye movement sleep (REM). Here, we provide a translation of these models into humans. Using the fear potentiated startle (FPS) procedure, we examined the effects of fear conditioning and safety signal learning on subsequent REM sleep in healthy adults. We also examined the effects of changes in REM sleep on retention of fear and safety learning. Participants (n = 42 normal controls) spent 3 consecutive nights in the laboratory. The first was an adaptation night. Following the second night, we administered a FPS procedure that included pairing a wrist shock with a threat signal and a safety signal never paired with a shock. The next day, we administered the FPS procedure again, with no wrist shocks to any stimulus, to measure retention of fear and safety. Canonical correlations assessed the relationship between FPS response and REM sleep. Results demonstrated that increased safety signal learning during the initial acquisition phase was associated with increased REM sleep consolidation that night, with 28.4 of the variance in increased REM sleep consolidation from baseline accounted for by safety signal learning. Overnight REM sleep was, in turn, related to overnight retention of fear and safety learning, with 22.5 of the variance in startle retention accounted for by REM sleep. These data suggest that sleep difficulties, specifically REM sleep fragmentation, may play a mechanistic role in post-traumatic stress disorder via an influence on safety signal learning and/or threat-safety discrimination
Original languageEnglish
Pages (from-to)11754-11760
Number of pages7
JournalJournal of Neuroscience
Volume34
Issue number35
DOIs
Publication statusPublished - 27 Aug 2014
Externally publishedYes

Cite this

Marshall, A. J., Acheson, D. T., Risbrough, V. B., Straus, L. D., & Drummond, S. P. A. (2014). Fear conditioning, safety learning, and sleep in humans. Journal of Neuroscience, 34(35), 11754-11760. https://doi.org/10.1523/JNEUROSCI.0478-14.2014
Marshall, Anisa J ; Acheson, Dean T ; Risbrough, Victoria B ; Straus, Laura D ; Drummond, Sean P.A. / Fear conditioning, safety learning, and sleep in humans. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 35. pp. 11754-11760.
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Marshall, AJ, Acheson, DT, Risbrough, VB, Straus, LD & Drummond, SPA 2014, 'Fear conditioning, safety learning, and sleep in humans' Journal of Neuroscience, vol. 34, no. 35, pp. 11754-11760. https://doi.org/10.1523/JNEUROSCI.0478-14.2014

Fear conditioning, safety learning, and sleep in humans. / Marshall, Anisa J; Acheson, Dean T; Risbrough, Victoria B; Straus, Laura D; Drummond, Sean P.A.

In: Journal of Neuroscience, Vol. 34, No. 35, 27.08.2014, p. 11754-11760.

Research output: Contribution to journalArticleResearchpeer-review

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