Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Natalie Trevaskis; Gary Nguyen; Martin Scanlon; Christopher Porter

doi:10.1007/s11095-011-0446-1

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Natalie Trevaskis, Gary Nguyen, Martin Scanlon, Christopher Porter

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Several poorly water-soluble drugs have previously been shown to bind to intestinal (I-FABP) and liver fatty acid binding protein (L-FABP) in vitro. The purpose of this study was to examine the potential role of drug binding to FABPs on intestinal permeability and gut wall metabolism in vivo.

Original language	English
Pages (from-to)	2176-2190
Number of pages	15
Journal	Pharmaceutical Research
Volume	28
Issue number	9
DOIs	https://doi.org/10.1007/s11095-011-0446-1
Publication status	Published - 2011

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10.1007/s11095-011-0446-1

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@article{2011930c12694c1ca7a6e0464af1ef34,

title = "Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?",

abstract = "Several poorly water-soluble drugs have previously been shown to bind to intestinal (I-FABP) and liver fatty acid binding protein (L-FABP) in vitro. The purpose of this study was to examine the potential role of drug binding to FABPs on intestinal permeability and gut wall metabolism in vivo.",

author = "Natalie Trevaskis and Gary Nguyen and Martin Scanlon and Christopher Porter",

year = "2011",

doi = "10.1007/s11095-011-0446-1",

language = "English",

volume = "28",

pages = "2176--2190",

journal = "Pharmaceutical Research",

issn = "0724-8741",