TY - JOUR
T1 - Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?
AU - Trevaskis, Natalie
AU - Nguyen, Gary
AU - Scanlon, Martin
AU - Porter, Christopher
PY - 2011
Y1 - 2011
N2 - Several poorly water-soluble drugs have previously
been shown to bind to intestinal (I-FABP) and liver fatty acid
binding protein (L-FABP) in vitro. The purpose of this study was
to examine the potential role of drug binding to FABPs on
intestinal permeability and gut wall metabolism in vivo.
AB - Several poorly water-soluble drugs have previously
been shown to bind to intestinal (I-FABP) and liver fatty acid
binding protein (L-FABP) in vitro. The purpose of this study was
to examine the potential role of drug binding to FABPs on
intestinal permeability and gut wall metabolism in vivo.
UR - http://www.springerlink.com/content/r7wr57126172317g/
U2 - 10.1007/s11095-011-0446-1
DO - 10.1007/s11095-011-0446-1
M3 - Article
SN - 0724-8741
VL - 28
SP - 2176
EP - 2190
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 9
ER -