Fatal ischemic stroke complicating acute multifocal placoid pigment epitheliopathy: Histopathological findings

Benjamin K T Tsang, Devinder S. Chauhan, Rebecca Haward, Ida Whiteman, Judith Frayne, Catriona McLean

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)


A previously healthy 29-year-old man was admitted to a tertiary referral center with acute left hemiparesis followed shortly by de novo convulsive status epilepticus. This was in the context of a 2-month history of flu-like symptoms, severe headaches, and retinopathy recently diagnosed as acute multifocal placoid pigment epitheliopathy. Neuroimaging demonstrated bilateral, multiple territory cerebral infarction. Despite intravenous methylprednisolone and craniotomy for the management of raised intracranial pressure, the patient deteriorated and died 14 days later. At autopsy, multiple infarcts of varying ages within a 10-day period were seen in association with a segmental giant cell vasculopathy of meningeal arteries.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalJournal of Neuro-Ophthalmology
Issue number1
Publication statusPublished - Mar 2014
Externally publishedYes

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