Fast computation of desired thermal dose: application to focused ultrasound-induced lesion planning

Jinao Zhang, Nha-Dat Bui, Wa Cheung, Stuart K. Roberts, Sunita Chauhan

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Computation of desired thermal dose can improve the safety and effectiveness of thermal therapeutic interventions while fast bio-heat in silico simulation can enhance the real-time surgical feedback. However, the existing methods are either computationally expensive or numerically inaccurate. This article presents a new methodology for fast and accurate desired thermal dose computation. New iterative algorithms are developed to adjust control parameters to efficiently obtain the desired lesion volumes, based on efficient solutions of bio-heat transfer in soft tissue. The variation of thermal dose is investigated using single- and multi-lesion configurations, and convergence analysis is presented. The clinically relevant scenario is demonstrated using a patient-specific simulation of focused ultrasound treatment of hepatic cancers to achieve multi-lesion planning (consistent and common lesion volumes in our case) for predictable and repeatable heat exposure sequence. The proposed method provides a common approach for fast iterative computation of single- or multiple-desired thermal lesions.
Original languageEnglish
Pages (from-to)666-682
Number of pages17
JournalNumerical Heat Transfer, Part A: Applications
Issue number6
Publication statusPublished - 4 Feb 2020

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