Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET

A.-M. Oros-Peusquens; F. Keil; K.J. Langen; H. Herzog; G. Stoffels; C. Weiss; N.J. Shah

doi:10.1016/j.nima.2013.09.045

Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET

A.-M. Oros-Peusquens, F. Keil, K.J. Langen, H. Herzog, G. Stoffels, C. Weiss, N.J. Shah

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue – obtained noninvasively with high precision and accuracy for the first time – amounted to 84.5%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2⁎ values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes of measurement time and is proposed for extended clinical use.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	734
Issue number	Part B
DOIs	https://doi.org/10.1016/j.nima.2013.09.045
Publication status	Published - 11 Jan 2014
Externally published	Yes

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10.1016/j.nima.2013.09.045

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Oros-Peusquens, A.-M., Keil, F., Langen, K. J., Herzog, H., Stoffels, G., Weiss, C., & Shah, N. J. (2014). Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 734(Part B), 185-190. https://doi.org/10.1016/j.nima.2013.09.045

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title = "Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET",

abstract = "The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue – obtained noninvasively with high precision and accuracy for the first time – amounted to 84.5\%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2⁎ values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes of measurement time and is proposed for extended clinical use.",

author = "A.-M. Oros-Peusquens and F. Keil and K.J. Langen and H. Herzog and G. Stoffels and C. Weiss and N.J. Shah",

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Oros-Peusquens, A-M, Keil, F, Langen, KJ, Herzog, H, Stoffels, G, Weiss, C & Shah, NJ 2014, 'Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 734, no. Part B, pp. 185-190. https://doi.org/10.1016/j.nima.2013.09.045

Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET. / Oros-Peusquens, A.-M.; Keil, F.; Langen, K.J. et al.
In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 734, No. Part B, 11.01.2014, p. 185-190.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET

AU - Oros-Peusquens, A.-M.

AU - Keil, F.

AU - Langen, K.J.

AU - Herzog, H.

AU - Stoffels, G.

AU - Weiss, C.

AU - Shah, N.J.

PY - 2014/1/11

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N2 - The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue – obtained noninvasively with high precision and accuracy for the first time – amounted to 84.5%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2⁎ values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes of measurement time and is proposed for extended clinical use.

AB - The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue – obtained noninvasively with high precision and accuracy for the first time – amounted to 84.5%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2⁎ values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes of measurement time and is proposed for extended clinical use.

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DO - 10.1016/j.nima.2013.09.045

M3 - Article

SN - 0168-9002

VL - 734

SP - 185

EP - 190

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

IS - Part B

ER -

Fast and accurate water content and T2* mapping in brain tumours localised with FET-PET

Abstract

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